Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	GRM4
Symbol Alias	GPRC1D, mGlu4, MGLUR4
Approved Name	glutamate receptor, metabotropic 4
Location	6p21.3
Position	chr6:34018645-34155622, -1
External Links	HGNC: 4596 Entrez Gene: 2914 Ensembl: ENSG00000124493 UCSC: uc011dsn.4
No. of Studies	2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Yosifova, A.,2009	SNP: rs1565366, rs2499724, rs3778068, rs3798529, rs733457	Significant association of SNP in this gene with BD in our population was observed.	Positive	Comment on Study
Fallin, M. D.,2005		6 SNP typed, Median D'=0.61, Median r<sup>2</sup> =0.08, 3 LD blocks, 0.24 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in SZ and in BP.. This gene is highly suggestive to BP and SZ/SZA.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 21)

GO terms by PBA (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007268	synaptic transmission	biological process	IEA	116
GO:0005516	calmodulin binding	molecular function	IEA	20
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0005887	integral component of plasma membrane	cellular component	IDA[15102938]	158

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0051966	regulation of synaptic transmission, glutamatergic	biological process	IBA	6
GO:0001642	group III metabotropic glutamate receptor activity	molecular function	IBA	3
GO:0000187	activation of MAPK activity	biological process	IDA[15102938]	14
GO:0004930	G-protein coupled receptor activity	molecular function	IMP[8738157]	26
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway	biological process	IMP[15102938]	5
GO:0008066	glutamate receptor activity	molecular function	IMP[8738157]	6
GO:0043195	terminal bouton	cellular component	IEA	17
GO:0048787	presynaptic active zone membrane	cellular component	IEA	1
GO:0043198	dendritic shaft	cellular component	IEA	7
GO:0007612	learning	biological process	IEA	18
GO:0042734	presynaptic membrane	cellular component	IBA	16
GO:0048306	calcium-dependent protein binding	molecular function	IEA	7
GO:0043523	regulation of neuron apoptotic process	biological process	TAS[15102938]	1
GO:0043410	positive regulation of MAPK cascade	biological process	IEP[15102938]	13
GO:0005622	intracellular	cellular component	IDA[15102938]	17
GO:0007269	neurotransmitter secretion	biological process	TAS[15102938]	15
GO:0031410	cytoplasmic vesicle	cellular component	IDA[15102938]	7

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04742	Taste transduction	7
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
GRM4	GNA15	NO	in vivo	8863838
GRM4	GNAQ	NO	in vivo	8863838
GRM4	CALM1	NO	in vitro;yeast 2-hybrid	15494036
GRM4	FLNA	NO	in vivo	11943148

Related other genetic factors

Gene related SNPs (count: 25)

Literature-origin SNPs (count: 5)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs733457	chr6:34100631 - 34100631(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	2(1/1/0)
rs3798529	chr6:34039120 - 34039120(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(1/0/0)
rs3778068	chr6:34060628 - 34060628(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs2499724	chr6:34118894 - 34118894(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)
rs1565366	chr6:34063906 - 34063906(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	1(1/0/0)

LD-proxies (count: 20)

rs_ID	Location	Functional Annotation
rs3887555	chr6:34101285 - 34101285(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs2395555	chr6:34100990 - 34100990(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs745501	chr6:34100942 - 34100942(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs9380406	chr6:34100015 - 34100015(1)	5_prime_UTR_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs6901097	chr6:34061271 - 34061271(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant
rs2451361	chr6:34061427 - 34061427(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs1109654	chr6:34106686 - 34106686(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs1075482	chr6:34107777 - 34107777(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs11753413	chr6:34105630 - 34105630(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs4713740	chr6:34117085 - 34117085(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs2499725	chr6:34119035 - 34119035(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs744102	chr6:34110686 - 34110686(1)	5_prime_UTR_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs2499722	chr6:34115682 - 34115682(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs2451337	chr6:34122784 - 34122784(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs2499726	chr6:34119859 - 34119859(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs4713742	chr6:34121817 - 34121817(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs1873254	chr6:34058712 - 34058712(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs4711374	chr6:34047988 - 34047988(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs9469693	chr6:34045473 - 34045473(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs9469690	chr6:34045134 - 34045134(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6p21	chr6:30500000-46200000	1 (0/1/0)
6p23-p21.1	chr6:13400000-46200000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
16380905	This gene is highly suggestive to BP and SZ/SZA.	Positive

Overlap with SZ from candidate gene intersection analysis (count: 3)

Reference	ID in SZGene	Result Category
19351574	371	Negative
16380905	371	Positive
11525421	371	Negative

Gene relationship with MDD

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Region: chr6:34018645..34155622 View in gBrowse