Gene Report

Basic Info
Approved Symbol GRM4
Symbol Alias GPRC1D, mGlu4, MGLUR4
Approved Name glutamate receptor, metabotropic 4
Location 6p21.3
Position chr6:34018645-34155622, -1
External Links HGNC: 4596
Entrez Gene: 2914
Ensembl: ENSG00000124493
UCSC: uc011dsn.4
No. of Studies 2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Yosifova, A.,2009 SNP: rs1565366, rs2499724, rs3778068, rs3798529, rs733457 Significant association of SNP in this gene with BD in our population was observed. Positive Comment on Study
Fallin, M. D.,2005 6 SNP typed, Median D'=0.61, Median r<sup>2</sup> =0.08, 3 LD blocks, 0.24 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in SZ and in BP.. This gene is highly suggestive to BP and SZ/SZA. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 21)

GO terms by PBA (count: 4)

GO terms by database search (count: 17)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 2)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Related other genetic factors
Gene related SNPs (count: 25)

Literature-origin SNPs (count: 5)

LD-proxies (count: 20)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 3)

Gene relationship with MDD

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Region: chr6:34018645..34155622 View in gBrowse
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