Gene Report

Basic Info
Approved Symbol HTR1A
Previous Symbol ADRB2RL1, ADRBRL1
Symbol Alias 5-HT1A
Approved Name 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
Previous Name 5-hydroxytryptamine (serotonin) receptor 1A
Location 5q11.2-q13
Position chr5:63960356-63962507, -1
External Links HGNC: 5286
Entrez Gene: 3350
Ensembl: ENSG00000178394
UCSC: uc011cqt.3
No. of Studies 3 (Positive: 2; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kishi, T.,2012(a) SNP: rs6295, rs878567 Results from this expanded meta-analysis, which included our own new study, suggest that rs6295 (C-1019G) and rs878567 in HTR1A are related to the pathophysiology of MDs, with overlap between MDD and BP. Findings provide additional clues to the underlying biology and treatment targets in MDs. Positive Comment on Study
Vincent, J. B.,1999(a) Other variant: HTR1A_(CA)n/(GT)n_10 No significant differences were found in bipolar groups. Negative Comment on Study
Kishi, T.,2011(b) SNP: rs6295, rs878567
Haplotype: rs6295 - rs878567(C-C), rs6295 - rs878567(G-C)
HTR1A may play an important role in the pathophysiology of BP, but not schizophrenia in the Japanese population. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 17)

GO terms by PBA (count: 2)

GO terms by database search (count: 15)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 7)

Related other genetic factors
Gene related SNPs (count: 6)

Literature-origin SNPs (count: 2)

LD-proxies (count: 4)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 5)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 8)

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Region: chr5:63960356..63962507 View in gBrowse
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