Gene Report

Basic Info
Approved Symbol NOTCH4
Previous Symbol INT3
Approved Name notch 4
Previous Name Notch (Drosophila) homolog 4, "Notch homolog 4 (Drosophila)"
Location 6p21.3
Position chr6:32194843-32224067, -1
External Links HGNC: 7884
Entrez Gene: 4855
Ensembl: ENSG00000204301
UCSC: uc003obb.3
No. of Studies 2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Swift-Scanlan, T., 2002 Other variant: NOTCH4_(CTG)n We failed to find any association between the (CTG)n NOTCH4 polymorphism and either the bipolar or the psychotic bipolar phenotype in our 65 pedigrees. Negative Comment on Study
Prathikanti, S.,2004 Other variant: NOTCH4_(CTG)n, NOTCH4_promoter_A>G These results do not support an association between genetic variation near NOTCH4 and BPAD in this sample. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 29)

GO terms by PBA (count: 6)

GO terms by database search (count: 23)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 11)

Related other genetic factors
Gene related SNPs (count: 2)

Literature-origin SNPs (count: 2)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 28)

Gene relationship with MDD

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Region: chr6:32194843..32224067 View in gBrowse
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