Gene Report

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Basic Info

Approved Symbol	HTR1F
Symbol Alias	HTR1EL, 5-HT1F
Approved Name	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
Previous Name	5-hydroxytryptamine (serotonin) receptor 1F
Location	3p12
Position	chr3:87990696-87993835, 1
External Links	HGNC: 5292 Entrez Gene: 3355 Ensembl: ENSG00000179097 UCSC: uc003dqr.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gratacos, M.,2009	SNP: rs1503433	Nominal associations with bipolar disorder was observed.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007268	synaptic transmission	biological process	TAS[8380639]	116
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0005887	integral component of plasma membrane	cellular component	IMP[21422162]	158

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007210	serotonin receptor signaling pathway	biological process	IDA[8380639]; IEA; IMP[21422162]	12
GO:0051378	serotonin binding	molecular function	IDA[8380639]	6
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	TAS[8380639]	17
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	biological process	IMP[21422162]	10
GO:0004993	serotonin receptor activity	molecular function	IDA[8380639]; IMP[21422162]	12

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
HTR1F	CAV1	NO	in vitro	15190056

Related other genetic factors

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1503433	chr3:87988050 - 87988050(1)	upstream_gene_variant	1(1/0/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs7629565		chr3:87995630 - 87995630(1)	downstream_gene_variant
rs2016224		chr3:87992500 - 87992500(1)	3_prime_UTR_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr3:87990696..87993835 View in gBrowse