Gene Report

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Basic Info

Approved Symbol	MBP
Approved Name	myelin basic protein
Location	18q23
Position	chr18:76978827-77133683, -1
External Links	HGNC: 6925 Entrez Gene: 4155 Ensembl: ENSG00000197971 UCSC: uc010xfd.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0010. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007268	synaptic transmission	biological process	TAS[2434243]	116
GO:0007417	central nervous system development	biological process	TAS[2434243]	21
GO:0042552	myelination	biological process	IEA	5
GO:0005886	plasma membrane	cellular component	IEA	360
GO:0005634	nucleus	cellular component	IEA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0033269	internode region of axon	cellular component	IEA	1
GO:0043025	neuronal cell body	cellular component	IEA	50
GO:0005515	protein binding	molecular function	IPI[17064692]	563
GO:0002020	protease binding	molecular function	IEA	10
GO:0043218	compact myelin	cellular component	IEA	1
GO:0061024	membrane organization	biological process	IEA	14
GO:0046689	response to mercury ion	biological process	IEA	1
GO:0008366	axon ensheathment	biological process	TAS[2434243]	2
GO:0050771	negative regulation of axonogenesis	biological process	IEA	5
GO:0021762	substantia nigra development	biological process	IEP[22926577]	7
GO:0007568	aging	biological process	IEA	22
GO:0070542	response to fatty acid	biological process	IEA	3
GO:0006955	immune response	biological process	TAS[7504278]	19
GO:0034612	response to tumor necrosis factor	biological process	IEA	3
GO:0019911	structural constituent of myelin sheath	molecular function	IEA	1
GO:0009636	response to toxic substance	biological process	IEA	12
GO:0032570	response to progesterone	biological process	IEA	5

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 40)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
MBP	SRPK1	NO	in vitro	10390541
MBP	MKNK1	NO	in vitro	9155018
MBP	CTDSP1	NO	in vitro;in vivo	14743429
MBP	PRKCD	NO	in vitro	11964256
MBP	RPS6KA5	NO	in vitro	9873047
MBP	IRAK1	NO	in vitro	10346818
MBP	MAPK1	NO	in vitro	9792705 , 12760422 , 15380617
MBP	MAPK14	NO	in vitro	15728454
MBP	MAPK13	NO	in vitro	9207191
MBP	PRKCI	NO	in vitro	10383403
MBP	MAPK11	NO	in vitro	15728454
MBP	PLP1	NO	in vitro	6083474 , 2467009
MBP	TLK1	NO	in vitro	10523312
MBP	CDK12	NO	in vitro	11683387
MBP	RTN4	YES	in vivo	12377379
MBP	RAN	NO	in vitro;in vivo	12101123
MBP	EFHA1	NO	in vitro	11124993
MBP	NEK9	NO	in vitro	11864968
MBP	TRAF6	NO	in vivo	10346818
MBP	PRKCA	NO	in vitro	2413024
MBP	MAG	NO	in vivo	12237860
MBP	MAPK3	NO	in vitro	10339476
MBP	PRMT1	NO	in vitro	4924231
MBP	MELK	NO	in vitro	16216881
MBP	STK4	NO	in vitro	7665586
MBP	MMP7	NO	in vitro	8786845
MBP	MAPKAPK5	NO	in vitro	9628874
MBP	PRMT5	NO	in vitro	11152681
MBP	STK16	NO	in vitro;in vivo	10947953
MBP	PRKACA	NO	in vitro	2413024
MBP	HLA-DRA	NO	in vitro	9782128
MBP	MAPK15	NO	in vitro	11875070
MBP	PAK1	NO	in vitro	14579272
MBP	TRPM7	NO	in vitro	14594813
MBP	TLK2	NO	in vitro	10523312
MBP	BMP2K	NO	in vitro	11500515
MBP	ATN1	NO	yeast 2-hybrid	16713569
MBP	CLK1	NO	in vitro	8798720
MBP	DYRK1B	NO	in vitro	10910078
MBP	APTX	NO	yeast 2-hybrid	16713569

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
18q	chr18:18500000-80373285	1 (0/1/0)
18q21-23	chr18:45900000-80373285	1 (1/0/0)
Chr 18	chr18:0-80373285	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	ID in SZGene	Result Category
17893707	633	Negative

Gene relationship with MDD

Reference	Description	Category in MDD	Link in MK4MDD
19605536	Downregulated in MDD patients	Pos	MBP
21912391	genes significantly affected in female MDD subjects	Pos	MBP

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Region: chr18:76978827..77133683 View in gBrowse