Gene Report

Basic Info
Approved Symbol BRCA2
Previous Symbol FANCD1, FACD, FANCD
Symbol Alias FAD, FAD1, BRCC2, XRCC11
Approved Name breast cancer 2, early onset
Previous Name Fanconi anemia, complementation group D1
Name Alias BRCA1/BRCA2-containing complex, subunit 2
Location 13q12-q13
Position chr13:32315474-32400266, 1
External Links HGNC: 1101
Entrez Gene: 675
Ensembl: ENSG00000139618
UCSC: uc001uub.1
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Tesli, M.,2010 SNP: rs9567552 Our findings support PALB2 and BRCA2 as risk genes specifically for BD, and suggest that altered DNA repair related to neurogenesis may be involved in BD pathophysiology. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 40)

GO terms by PBA (count: 2)

GO terms by database search (count: 38)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 2)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

Gene related interactors from protein-protein interactions data in HPRD (count: 23)

Related other genetic factors
Gene related SNPs (count: 2)

Literature-origin SNPs (count: 1)

LD-proxies (count: 1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr13:32315474..32400266 View in gBrowse
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