Gene Report

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Basic Info

Approved Symbol	MTNR1A
Symbol Alias	MEL-1A-R
Approved Name	melatonin receptor 1A
Location	4q35
Position	chr4:186533655-186555567, -1
External Links	HGNC: 7463 Entrez Gene: 4543 Ensembl: ENSG00000168412 UCSC: uc003izd.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Abou Jamra, R, 2008 (a)	SNP: rs11721818, rs13113549, rs13140444, rs1946977, rs1946979, rs2119882, rs2165668, rs4861722, rs4862706, rs4862709, rs4862711, rs6553010, rs6553013, rs6820205, rs7665239	No significant association was observed for SNPs located in the MTNR1A gene	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0043235	receptor complex	cellular component	IDA[10531408]	20
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0005887	integral component of plasma membrane	cellular component	IDA[10531408]	158

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007623	circadian rhythm	biological process	TAS[9645677]	40
GO:0007617	mating behavior	biological process	TAS[7946354]	4
GO:0097159	organic cyclic compound binding	molecular function	IPI[10531408]	1
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	TAS[9645677]	17
GO:0008502	melatonin receptor activity	molecular function	IEA	2
GO:0005515	protein binding	molecular function	IPI[20859254]	563
GO:0030828	positive regulation of cGMP biosynthetic process	biological process	IDA[10531408]	2
GO:0042562	hormone binding	molecular function	IPI[10531408]	3

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 24)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
MTNR1A	CNP	NO	in vivo	17215244
MTNR1A	EEF1G	NO	in vivo	17215244
MTNR1A	VAPB	NO	in vivo	17215244
MTNR1A	CALR	NO	in vivo	17215244
MTNR1A	GNB1	NO	in vivo	17215244
MTNR1A	HSPA5	YES	in vivo	17215244
MTNR1A	PGRMC1	NO	in vivo	17215244
MTNR1A	HNRNPA0	NO	in vivo	17215244
MTNR1A	DPM1	NO	in vitro	17215244
MTNR1A	PDIA6	NO	in vivo	17215244
MTNR1A	CANX	NO	in vivo	17215244
MTNR1A	GPR50	YES	in vitro;in vivo	16778767
MTNR1A	MTNR1B	NO	in vivo	15266022
MTNR1A	IRS4	NO	in vivo	17215244
MTNR1A	GNB4	NO	in vivo	17215244
MTNR1A	FLNA	NO	in vivo	17215244
MTNR1A	LRRC59	NO	in vivo	17215244
MTNR1A	RAB10	NO	in vivo	17215244
MTNR1A	GNA13	NO	in vivo	10598579
MTNR1A	GNA11	NO	in vivo	10598579
MTNR1A	GNAI3	NO	in vitro;in vivo	10598579 , 17215244
MTNR1A	GNAI1	NO	in vivo	17215244
MTNR1A	RAP1A	NO	in vivo	17215244
MTNR1A	TMEM33	NO	in vivo	17215244

Related other genetic factors

Gene related SNPs (count: 22)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2165668	chr4:186533547 - 186533547(1)	downstream_gene_variant; intron_variant	1(0/1/0)
rs7665239	chr4:186561491 - 186561491(1)		1(0/1/0)
rs13113549	chr4:186544837 - 186544837(1)	intron_variant	1(0/1/0)
rs1946977	chr4:186527981 - 186527981(1)	intron_variant	1(0/1/0)
rs11721818	chr4:186556166 - 186556166(1)	upstream_gene_variant	1(0/1/0)
rs4862706	chr4:186552540 - 186552540(1)	intron_variant	1(0/1/0)
rs4862709	chr4:186557698 - 186557698(1)	upstream_gene_variant	1(0/1/0)
rs1946979	chr4:186528131 - 186528131(1)	intron_variant	1(0/1/0)
rs2119882	chr4:186555751 - 186555751(1)	upstream_gene_variant	1(0/1/0)
rs13140444	chr4:186544575 - 186544575(1)	intron_variant	1(0/1/0)
rs4861722	chr4:186568229 - 186568229(1)		1(0/1/0)
rs6553010	chr4:186535189 - 186535189(1)	intron_variant	1(0/1/0)
rs4862711	chr4:186560470 - 186560470(1)	upstream_gene_variant	1(0/1/0)
rs6553013	chr4:186563717 - 186563717(1)		1(0/1/0)
rs6820205	chr4:186543713 - 186543713(1)	intron_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs6553008	chr4:186534792 - 186534792(1)	intron_variant
rs6553009	chr4:186534966 - 186534966(1)	intron_variant
rs2119883	chr4:186547921 - 186547921(1)	intron_variant
rs6838290	chr4:186530387 - 186530387(1)	downstream_gene_variant; intron_variant
rs2375801	chr4:186550471 - 186550471(1)	intron_variant
rs13113915	chr4:186544810 - 186544810(1)	intron_variant
rs13140012	chr4:186544404 - 186544404(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 4	chr4:0-190214555	3 (0/3/0)
4q35	chr4:182300000-190214555	4 (0/1/3)
4q31-35	chr4:138500000-190214555	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr4:186533655..186555567 View in gBrowse