Gene Report

Basic Info
Approved Symbol DPYSL2
Symbol Alias DRP-2, DHPRP2, CRMP2, DRP2
Approved Name dihydropyrimidinase-like 2
Location 8p22-p21
Position chr8:26514022-26658178, 1
External Links HGNC: 3014
Entrez Gene: 1808
Ensembl: ENSG00000092964
UCSC: uc003xfa.3
No. of Studies 2 (Positive: 1; Negative: 0; trend: 1)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Fallin, M. D.,2005 8 SNP typed, Median D'=0.65, Median r<sup>2</sup> =0.08, 4 LD blocks, 0.57 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in SZ and P-value > 0.01 and <0.05 in BP.. This gene is highly suggestive to SZ/SZA and suggestive to BP. Trend Comment on Study
Yosifova, A.,2009 SNP: rs11863, rs17666, rs327232, rs920697 Significant association of SNP in this gene with BD in our population was observed. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 27)

GO terms by PBA (count: 3)

GO terms by database search (count: 24)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Related other genetic factors
Gene related SNPs (count: 11)

Literature-origin SNPs (count: 4)

LD-proxies (count: 7)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 5)

Gene relationship with MDD

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Region: chr8:26514022..26658178 View in gBrowse
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