Gene Report

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Basic Info

Approved Symbol	DPYSL2
Symbol Alias	DRP-2, DHPRP2, CRMP2, DRP2
Approved Name	dihydropyrimidinase-like 2
Location	8p22-p21
Position	chr8:26514022-26658178, 1
External Links	HGNC: 3014 Entrez Gene: 1808 Ensembl: ENSG00000092964 UCSC: uc003xfa.3
No. of Studies	2 (Positive: 1; Negative: 0; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fallin, M. D.,2005		8 SNP typed, Median D'=0.65, Median r<sup>2</sup> =0.08, 4 LD blocks, 0.57 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in SZ and P-value > 0.01 and <0.05 in BP.. This gene is highly suggestive to SZ/SZA and suggestive to BP.	Trend	Comment on Study
Yosifova, A.,2009	SNP: rs11863, rs17666, rs327232, rs920697	Significant association of SNP in this gene with BD in our population was observed.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007411	axon guidance	biological process	TAS	60
GO:0007399	nervous system development	biological process	TAS[8973361]	40
GO:0016020	membrane	cellular component	IDA[20801876]	137

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007165	signal transduction	biological process	TAS[8973361]	136
GO:0048489	synaptic vesicle transport	biological process	IEA	3
GO:0043025	neuronal cell body	cellular component	IEA	50
GO:0005515	protein binding	molecular function	IPI[16260607]	563
GO:0021772	olfactory bulb development	biological process	IEA	4
GO:0042220	response to cocaine	biological process	IEA	12
GO:0030425	dendrite	cellular component	IEA	65
GO:0007010	cytoskeleton organization	biological process	ISS	11
GO:0070062	extracellular vesicular exosome	cellular component	IDA[20458337]	176
GO:0043195	terminal bouton	cellular component	IEA	17
GO:0019901	protein kinase binding	molecular function	IEA	29
GO:0006139	nucleobase-containing compound metabolic process	biological process	TAS[8973361]	2
GO:0001975	response to amphetamine	biological process	IEA	19
GO:0006897	endocytosis	biological process	IMP[20801876]	15
GO:0005829	cytosol	cellular component	IDA[20801876]; TAS	223
GO:0010975	regulation of neuron projection development	biological process	IEA	4
GO:0005739	mitochondrion	cellular component	IEA	75
GO:0004157	dihydropyrimidinase activity	molecular function	TAS[8973361]	1
GO:0014049	positive regulation of glutamate secretion	biological process	IEA	2
GO:0021510	spinal cord development	biological process	IEA	2
GO:0030426	growth cone	cellular component	IEA	22
GO:0005874	microtubule	cellular component	IDA[20801876]	24
GO:0006208	pyrimidine nucleobase catabolic process	biological process	IEA	1
GO:0042493	response to drug	biological process	IEA	57

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04360	Axon guidance	16

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
DPYSL2	TUBB	YES	in vitro;in vivo	12134159
DPYSL2	ROCK1	NO	in vitro;in vivo	12482610 , 10818093
DPYSL2	DPYSL5	NO	in vivo	10956643
DPYSL2	CRMP1	NO	in vivo	12482610
DPYSL2	PLD2	NO	in vitro;in vivo	11741937

Related other genetic factors

Gene related SNPs (count: 11)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs920697	chr8:26579560 - 26579560(1)	intron_variant	1(0/1/0)
rs11863	chr8:26656800 - 26656800(1)	3_prime_UTR_variant; downstream_gene_variant	1(1/0/0)
rs327232	chr8:26598199 - 26598199(1)	intron_variant	1(0/1/0)
rs17666	chr8:26657942 - 26657942(1)	3_prime_UTR_variant; downstream_gene_variant	1(1/0/0)

rs_ID	Location	Functional Annotation
rs327214	chr8:26611114 - 26611114(1)	intron_variant
rs12680365	chr8:26522543 - 26522543(1)	intron_variant
rs13249662	chr8:26662365 - 26662365(1)	downstream_gene_variant
rs7827731	chr8:26658377 - 26658377(1)	downstream_gene_variant
rs4872450	chr8:26519339 - 26519339(1)	intron_variant
rs10108849	chr8:26561080 - 26561080(1)	intron_variant
rs4872453	chr8:26556473 - 26556473(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
8p21	chr8:19200000-29000000	2 (0/1/1)
Chr 8	chr8:0-145138636	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16380905	This gene is highly suggestive to SZ/SZA and suggestive to BP.	Positive

Gene relationship with MDD

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Region: chr8:26514022..26658178 View in gBrowse