Gene Report

Basic Info
Approved Symbol DAO
Symbol Alias DAMOX
Approved Name D-amino-acid oxidase
Location 12q24.11
Position chr12:108858932-108901043, 1
External Links HGNC: 2671
Entrez Gene: 1610
Ensembl: ENSG00000110887
UCSC: uc001tnr.4
No. of Studies 5 (Positive: 1; Negative: 4; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 5)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Schumacher, J.,2004 Haplotype: MDAAO4 - MDAAO5 - MDAAO6(A-C-G), MDAAO4 - MDAAO5 - MDAAO6(A-C-T), MDAAO4 - MDAAO5 - MDAAO6(C-C-G), MDAAO4 - MDAAO5 - MDAAO6(C-T-T)
DAAO was associated with schizophrenia, but not with BPAD. Negative Comment on Study
Gaysina, D.,2010 SNP: rs3741775
Haplotype: rs1935062 - rs3741775(), rs3916965 - rs3741775()
In conclusion, our results in two independent Caucasian samples did not provide evidence for association of DAOA or DAO with BD, nor did we find convincing evidence of statistical epitasis. Negative Comment on Study
Prata, D., 2008 SNP: rs2111902, rs3741775, rs3918346, rs3918347
Haplotype: rs2111902 - rs3918346(), rs2111902 - rs3918346(2-2: A-T), rs2111902 - rs3918346 - rs3741775(), rs2111902 - rs3918346 - rs3741775(2-2-1: A-T-T), rs2111902 - rs3918346 - rs3916972(), rs2111902 - rs3918346 - rs3916972(2-2-1: A-T-A)
Analysis of each SNP individually showed no significant association. Negative Comment on Study
Papagni, S. A.,2011 SNP: rs3918346 There were no significant effects of diagnosis or of genotype in comparisons involving bipolar patients. Negative Comment on Study
Fallin, M. D.,2005 5 SNP typed, Median D'=0.89, Median r<sup>2</sup> =0.26, 2 LD blocks, 0.27 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in BP and all SNP or haplotype P-value > 0.05 in SZ/SZA.. This gene is highly suggestive to BP , not suggestive to SZ/SZA. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 21)

GO terms by PBA (count: 2)

GO terms by database search (count: 19)

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 2)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Related other genetic factors
Gene related SNPs (count: 9)

Literature-origin SNPs (count: 4)

LD-proxies (count: 5)

Gene related CNVs (count: 0)

Gene related other variants (count: 3)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 3)

Overlap with SZ from candidate gene intersection analysis (count: 15)

Gene relationship with MDD

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Region: chr12:108858932..108901043 View in gBrowse
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