Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	INHBB
Approved Name	inhibin, beta B
Previous Name	inhibin, beta B (activin AB beta polypeptide)
Location	2q14.2
Position	chr2:120346143-120351808, 1
External Links	HGNC: 6067 Entrez Gene: 3625 Ensembl: ENSG00000163083 UCSC: uc002tmn.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gonzalez, S., 2014	SNP: rs1880542	The associated SNP in this gene showed no significant association with BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 32)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005125	cytokine activity	molecular function	TAS[3122219]	13
GO:0005179	hormone activity	molecular function	TAS[3122219]	12
GO:0030154	cell differentiation	biological process	NAS[10320815]	31

GO terms by database search (count: 29)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006952	defense response	biological process	TAS[3122219]	2
GO:0060279	positive regulation of ovulation	biological process	ISS	1
GO:0046882	negative regulation of follicle-stimulating hormone secretion	biological process	IPI[3122219]	1
GO:0001541	ovarian follicle development	biological process	NAS[12790766]	4
GO:0046789	host cell surface receptor binding	molecular function	TAS[12456957]	1
GO:0048178	negative regulation of hepatocyte growth factor biosynthetic process	biological process	IDA[12419948]	1
GO:0048471	perinuclear region of cytoplasm	cellular component	IDA[16650820]	50
GO:0060395	SMAD protein signal transduction	biological process	IBA	4
GO:0048599	oocyte development	biological process	IEA	2
GO:0043408	regulation of MAPK cascade	biological process	IBA	6
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	biological process	IBA	2
GO:0005515	protein binding	molecular function	IPI[12697670]	563
GO:0005160	transforming growth factor beta receptor binding	molecular function	IBA	2
GO:0005615	extracellular space	cellular component	IBA	85
GO:0009612	response to mechanical stimulus	biological process	IDA[10320815]	7
GO:0032924	activin receptor signaling pathway	biological process	IDA[16650820]	1
GO:0042981	regulation of apoptotic process	biological process	IBA	10
GO:0040007	growth	biological process	IEA	4
GO:0009267	cellular response to starvation	biological process	ISS	6
GO:2001235	positive regulation of apoptotic signaling pathway	biological process	IEA	2
GO:0045444	fat cell differentiation	biological process	ISS	6
GO:0044320	cellular response to leptin stimulus	biological process	IEA	1
GO:0008083	growth factor activity	molecular function	IEA	15
GO:0005576	extracellular region	cellular component	TAS[3122219]	97
GO:0046676	negative regulation of insulin secretion	biological process	ISS	4
GO:0048468	cell development	biological process	IBA	1
GO:0046881	positive regulation of follicle-stimulating hormone secretion	biological process	IPI[3122219]	1
GO:0032869	cellular response to insulin stimulus	biological process	ISS	12
GO:0042803	protein homodimerization activity	molecular function	IPI[2575216]	71

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04350	TGF-beta signaling pathway	10

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04060	Cytokine-cytokine receptor interaction	17

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 9)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
INHBB	ACVR2B	NO	in vivo	9202237
INHBB	INHBA	NO	in vitro	11134153
INHBB	ACVR2A	NO	in vivo	11266516
INHBB	ACVR1C	NO	in vitro	15196700
INHBB	ACVR1B	NO	in vivo	11266516 , 12032389 , 15196700
INHBB	IGSF1	NO	in vivo	11266516
INHBB	INHA	NO	in vitro	11134153
INHBB	INHBC	NO	in vitro	11134153
INHBB	ACVR1	NO	in vivo	11266516

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1880542	chr2:120581008 - 120581008(1)		1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2q12.3-q22.1	chr2:106700000-141500000	1 (0/1/0)
Chr 2	chr2:0-242193529	3 (0/3/0)
2p11-q14	chr2:83100000-129100000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:120346143..120351808 View in gBrowse