Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	STK39
Symbol Alias	DCHT, SPAK
Approved Name	serine threonine kinase 39
Name Alias	STE20/SPS1 homolog (yeast)
Location	2q24.3
Position	chr2:167954020-168248141, -1
External Links	HGNC: 17717 Entrez Gene: 27347 Ensembl: ENSG00000198648 UCSC: uc002uea.3
No. of Studies	2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Sklar, P.,2011	SNP: rs4668059	No significant association was observed.	Negative	Comment on Study
Green, E. K.,2012	SNP: rs4668059	BD ImmunoChip:P-value = 0.731,OR = 1.026;ImmunoChip, PGC-BD combined data:P-balue = 0.00023,OR = 1.107 No significant association was observed.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 23)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004674	protein serine/threonine kinase activity	molecular function	IDA[24393035]	27
GO:0005634	nucleus	cellular component	NAS[10980603]	283

GO terms by database search (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005737	cytoplasm	cellular component	IBA; NAS[10980603]	322
GO:2000681	negative regulation of rubidium ion transport	biological process	IDA[24393035]	1
GO:0023014	signal transduction by phosphorylation	biological process	IDA[24393035]	5
GO:0006950	response to stress	biological process	NAS[10980603]	5
GO:1901380	negative regulation of potassium ion transmembrane transport	biological process	IDA[24393035]	1
GO:0005524	ATP binding	molecular function	IEA	118
GO:0018105	peptidyl-serine phosphorylation	biological process	IDA[24393035]	11
GO:0006468	protein phosphorylation	biological process	NAS[10980603]	42
GO:0004702	receptor signaling protein serine/threonine kinase activity	molecular function	IBA; NAS[10980603]	5
GO:0016324	apical plasma membrane	cellular component	IEA	24
GO:2000687	negative regulation of rubidium ion transmembrane transporter activity	biological process	IDA[24393035]	1
GO:0035556	intracellular signal transduction	biological process	IDA[24393035]	38
GO:0018107	peptidyl-threonine phosphorylation	biological process	IDA[24393035]	3
GO:0050727	regulation of inflammatory response	biological process	IEA	4
GO:0043268	positive regulation of potassium ion transport	biological process	IEA	6
GO:1901017	negative regulation of potassium ion transmembrane transporter activity	biological process	IDA[24393035]	1
GO:0019901	protein kinase binding	molecular function	IEA	29
GO:0071476	cellular hypotonic response	biological process	IC[24393035]	3
GO:0016323	basolateral plasma membrane	cellular component	IEA	21
GO:0005856	cytoskeleton	cellular component	IEA	30
GO:0005515	protein binding	molecular function	IPI[21423148]	563

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
STK39	WNK4	NO	yeast 2-hybrid	15930150
STK39	SLC12A1	NO	yeast 2-hybrid	12386165
STK39	MAPK14	NO	in vitro	10980603
STK39	PRKCQ	NO	in vitro;in vivo	10980603
STK39	MBP	YES	in vitro;in vivo	10980603
STK39	RELT	NO	in vitro;in vivo;yeast 2-hybrid	16530727
STK39	SLC12A6	YES	yeast 2-hybrid	12386165
STK39	SLC12A2	NO	in vitro;in vivo;yeast 2-hybrid	14563843

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4668059	chr2:168309772 - 168309772(1)		2(0/2/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2q24.3	chr2:162900000-168900000	1 (0/0/1)
2q24	chr2:154000000-168900000	4 (0/3/1)
2q21-q33	chr2:129100000-208200000	1 (0/0/1)
Chr 2	chr2:0-242193529	3 (0/3/0)
2q24-33	chr2:154000000-208200000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:167954020..168248141 View in gBrowse