Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

ADD to My Gene Set

Comment on Gene

View All Comments on Gene

Basic Info

Approved Symbol	DCC
Symbol Alias	IGDCC1, NTN1R1
Approved Name	DCC netrin 1 receptor
Previous Name	deleted in colorectal carcinoma
Name Alias	immunoglobulin superfamily, DCC subclass, member 1
Location	18q21.1
Position	chr18:52340172-53535903, 1
External Links	HGNC: 2701 Entrez Gene: 1630 Ensembl: ENSG00000187323 UCSC: uc002lfe.2
No. of Studies	2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Kuo, P. H., 2014	SNP: rs1222938	Gene-based P-value (allelic model) = 0.4426, P-value (additive model) =0.4147. DCC stood out for their potential biological plausibility to be associated with bipolar illness.	Negative	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0176. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 29)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0007411	axon guidance	biological process	TAS	60

GO terms by database search (count: 26)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005042	netrin receptor activity	molecular function	IEA	1
GO:1901214	regulation of neuron death	biological process	IMP[21085126]	2
GO:0001764	neuron migration	biological process	IEA	18
GO:0042802	identical protein binding	molecular function	IEA	44
GO:0033563	dorsal/ventral axon guidance	biological process	IEA	1
GO:1903506	regulation of nucleic acid-templated transcription	biological process	IEA	1
GO:0097190	apoptotic signaling pathway	biological process	TAS	13
GO:0033564	anterior/posterior axon guidance	biological process	IEA	1
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological process	IEA	14
GO:2000171	negative regulation of dendrite development	biological process	TAS[19616629]	2
GO:0043065	positive regulation of apoptotic process	biological process	TAS	25
GO:0005829	cytosol	cellular component	TAS	223
GO:0004888	transmembrane signaling receptor activity	molecular function	TAS[8861902]	10
GO:0007409	axonogenesis	biological process	TAS[8861902]	11
GO:0001975	response to amphetamine	biological process	IEA	19
GO:0003713	transcription coactivator activity	molecular function	IEA	22
GO:0010976	positive regulation of neuron projection development	biological process	IEA	10
GO:0010977	negative regulation of neuron projection development	biological process	TAS[19616629]	4
GO:0032584	growth cone membrane	cellular component	IEA	2
GO:0045121	membrane raft	cellular component	IEA	22
GO:0048671	negative regulation of collateral sprouting	biological process	TAS[19616629]	2
GO:0038007	netrin-activated signaling pathway	biological process	IEA	1
GO:0030424	axon	cellular component	IEA	39
GO:0021965	spinal cord ventral commissure morphogenesis	biological process	IEA	2
GO:0005515	protein binding	molecular function	IPI[11527412]	563
GO:0006915	apoptotic process	biological process	TAS[9796814]	39

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa05210	Colorectal cancer	14
hsa04360	Axon guidance	16

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 11)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
DCC	MAZ	NO	in vitro;in vivo;yeast 2-hybrid	12509857 , 11527412
DCC	NTN1	NO	in vitro	9950216 , 12810718
DCC	CASP3	NO	in vitro;in vivo;yeast 2-hybrid	11248093
DCC	PITPNA	NO	in vitro;in vivo;yeast 2-hybrid	16244667
DCC	CASP9	NO	in vitro;in vivo;yeast 2-hybrid	11248093
DCC	PTK2	NO	in vitro;in vivo	15494733
DCC	SIAH1	NO	in vitro;in vivo	9858595
DCC	MAPK3	NO	in vitro;in vivo	11986622
DCC	APPL1	NO	in vivo;yeast 2-hybrid	12011067
DCC	NCK1	NO	in vitro	12149262
DCC	SIAH2	NO	in vitro	9858595

Related other genetic factors

Gene related SNPs (count: 11)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1222938	chr18:52414796 - 52414796(1)	downstream_gene_variant; intron_variant	1(1/0/0)

LD-proxies (count: 10)

rs_ID	Location	Functional Annotation
rs3862679	chr18:52403951 - 52403951(1)	intron_variant
rs8094822	chr18:52393914 - 52393914(1)	intron_variant
rs3862682	chr18:52407792 - 52407792(1)	intron_variant; upstream_gene_variant
rs9948092	chr18:52406750 - 52406750(1)	intron_variant; upstream_gene_variant
rs3862681	chr18:52404320 - 52404320(1)	intron_variant; upstream_gene_variant
rs3862680	chr18:52403970 - 52403970(1)	intron_variant
rs3862683	chr18:52408935 - 52408935(1)	intron_variant; upstream_gene_variant
rs1789666	chr18:52411721 - 52411721(1)	downstream_gene_variant; intron_variant
rs3851129	chr18:52408487 - 52408487(1)	intron_variant; upstream_gene_variant
rs3851127	chr18:52408004 - 52408004(1)	intron_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 8)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
18q	chr18:18500000-80373285	1 (0/1/0)
18q12.3-q21.1	chr18:39500000-63900000	1 (1/0/0)
18q12-21	chr18:27500000-63900000	1 (0/1/0)
18q12.3-q22.1	chr18:39500000-69100000	1 (0/1/0)
18q21	chr18:45900000-63900000	3 (2/1/0)
18q21-23	chr18:45900000-80373285	1 (1/0/0)
18q21-q22	chr18:45900000-75400000	1 (0/1/0)
Chr 18	chr18:0-80373285	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr18:52340172..53535903 View in gBrowse