Gene Report

Basic Info
Approved Symbol DCC
Symbol Alias IGDCC1, NTN1R1
Approved Name DCC netrin 1 receptor
Previous Name deleted in colorectal carcinoma
Name Alias immunoglobulin superfamily, DCC subclass, member 1
Location 18q21.1
Position chr18:52340172-53535903, 1
External Links HGNC: 2701
Entrez Gene: 1630
Ensembl: ENSG00000187323
UCSC: uc002lfe.2
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kuo, P. H., 2014 SNP: rs1222938 Gene-based P-value (allelic model) = 0.4426, P-value (additive model) =0.4147. DCC stood out for their potential biological plausibility to be associated with bipolar illness. Negative Comment on Study
Johnson, C.,2009 Monte-Carlo Simulation P-value = 0.0176. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 29)

GO terms by PBA (count: 3)

GO terms by database search (count: 26)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 2)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 11)

Related other genetic factors
Gene related SNPs (count: 11)

Literature-origin SNPs (count: 1)

LD-proxies (count: 10)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 8)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr18:52340172..53535903 View in gBrowse
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