Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	DCC
Symbol Alias	IGDCC1, NTN1R1
Approved Name	DCC netrin 1 receptor
Previous Name	deleted in colorectal carcinoma
Name Alias	immunoglobulin superfamily, DCC subclass, member 1
Location	18q21.1
Position	chr18:52340172-53535903, 1
External Links	HGNC: 2701 Entrez Gene: 1630 Ensembl: ENSG00000187323 UCSC: uc002lfe.2
No. of Studies	2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Kuo, P. H., 2014	SNP: rs1222938	Gene-based P-value (allelic model) = 0.4426, P-value (additive model) =0.4147. DCC stood out for their potential biological plausibility to be associated with bipolar illness.	Negative	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0176. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 29)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0007411	axon guidance	biological process	TAS	60

GO terms by database search (count: 26)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005042	netrin receptor activity	molecular function	IEA	1
GO:1901214	regulation of neuron death	biological process	IMP[21085126]	2
GO:0001764	neuron migration	biological process	IEA	18
GO:0042802	identical protein binding	molecular function	IEA	44
GO:0033563	dorsal/ventral axon guidance	biological process	IEA	1
GO:1903506	regulation of nucleic acid-templated transcription	biological process	IEA	1
GO:0097190	apoptotic signaling pathway	biological process	TAS	13
GO:0033564	anterior/posterior axon guidance	biological process	IEA	1
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological process	IEA	14
GO:2000171	negative regulation of dendrite development	biological process	TAS[19616629]	2
GO:0043065	positive regulation of apoptotic process	biological process	TAS	25
GO:0005829	cytosol	cellular component	TAS	223
GO:0004888	transmembrane signaling receptor activity	molecular function	TAS[8861902]	10
GO:0007409	axonogenesis	biological process	TAS[8861902]	11
GO:0001975	response to amphetamine	biological process	IEA	19
GO:0003713	transcription coactivator activity	molecular function	IEA	22
GO:0010976	positive regulation of neuron projection development	biological process	IEA	10
GO:0010977	negative regulation of neuron projection development	biological process	TAS[19616629]	4
GO:0032584	growth cone membrane	cellular component	IEA	2
GO:0045121	membrane raft	cellular component	IEA	22
GO:0048671	negative regulation of collateral sprouting	biological process	TAS[19616629]	2
GO:0038007	netrin-activated signaling pathway	biological process	IEA	1
GO:0030424	axon	cellular component	IEA	39
GO:0021965	spinal cord ventral commissure morphogenesis	biological process	IEA	2
GO:0005515	protein binding	molecular function	IPI[11527412]	563
GO:0006915	apoptotic process	biological process	TAS[9796814]	39

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa05210	Colorectal cancer	14
hsa04360	Axon guidance	16

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 11)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
DCC	CASP3	NO	in vitro;in vivo;yeast 2-hybrid	11248093
DCC	CASP9	NO	in vitro;in vivo;yeast 2-hybrid	11248093
DCC	MAPK3	NO	in vitro;in vivo	11986622
DCC	NTN1	NO	in vitro	9950216 , 12810718
DCC	NCK1	NO	in vitro	12149262
DCC	PITPNA	NO	in vitro;in vivo;yeast 2-hybrid	16244667
DCC	SIAH1	NO	in vitro;in vivo	9858595
DCC	SIAH2	NO	in vitro	9858595
DCC	PTK2	NO	in vitro;in vivo	15494733
DCC	MAZ	NO	in vitro;in vivo;yeast 2-hybrid	12509857 , 11527412
DCC	APPL1	NO	in vivo;yeast 2-hybrid	12011067

Related other genetic factors

Gene related SNPs (count: 11)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1222938	chr18:52414796 - 52414796(1)	downstream_gene_variant; intron_variant	1(1/0/0)

LD-proxies (count: 10)

rs_ID	Location	Functional Annotation
rs3862679	chr18:52403951 - 52403951(1)	intron_variant
rs8094822	chr18:52393914 - 52393914(1)	intron_variant
rs3862682	chr18:52407792 - 52407792(1)	intron_variant; upstream_gene_variant
rs9948092	chr18:52406750 - 52406750(1)	intron_variant; upstream_gene_variant
rs3862681	chr18:52404320 - 52404320(1)	intron_variant; upstream_gene_variant
rs3862680	chr18:52403970 - 52403970(1)	intron_variant
rs3862683	chr18:52408935 - 52408935(1)	intron_variant; upstream_gene_variant
rs1789666	chr18:52411721 - 52411721(1)	downstream_gene_variant; intron_variant
rs3851129	chr18:52408487 - 52408487(1)	intron_variant; upstream_gene_variant
rs3851127	chr18:52408004 - 52408004(1)	intron_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 8)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
18q	chr18:18500000-80373285	1 (0/1/0)
18q12.3-q21.1	chr18:39500000-63900000	1 (1/0/0)
18q12-21	chr18:27500000-63900000	1 (0/1/0)
18q12.3-q22.1	chr18:39500000-69100000	1 (0/1/0)
18q21	chr18:45900000-63900000	3 (2/1/0)
18q21-23	chr18:45900000-80373285	1 (1/0/0)
18q21-q22	chr18:45900000-75400000	1 (0/1/0)
Chr 18	chr18:0-80373285	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr18:52340172..53535903 View in gBrowse