Gene Report

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Basic Info

Approved Symbol	TPST2
Symbol Alias	TANGO13B
Approved Name	tyrosylprotein sulfotransferase 2
Name Alias	transport and golgi organization 13 homolog B (Drosophila)
Location	22q12.1
Position	chr22:26521983-26596717, -1
External Links	HGNC: 12021 Entrez Gene: 8459 Ensembl: ENSG00000128294 UCSC: uc003acx.3
No. of Studies	2 (Positive: 1; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Georgi, B., 2014	SNP: rs117701840	Amish-specific putative damaging exonic missense variant was found within this gene.	Trend	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0077. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016020	membrane	cellular component	TAS[9736702]	137
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008476	protein-tyrosine sulfotransferase activity	molecular function	IEA	1
GO:0006478	peptidyl-tyrosine sulfation	biological process	IEA	1
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0007342	fusion of sperm to egg plasma membrane	biological process	IEA	1
GO:0000139	Golgi membrane	cellular component	IEA	36
GO:0005783	endoplasmic reticulum	cellular component	IDA	49
GO:0060468	prevention of polyspermy	biological process	IEA	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TPST2	SELPLG	NO	in vitro	17558413
TPST2	GPR1	NO	in vitro	17558413
TPST2	CCR2	NO	in vitro	17558413
TPST2	CCR1	NO	in vitro	17558413
TPST2	CCR8	NO	in vitro	17558413

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs117701840	chr22:26541173 - 26541173(1)	downstream_gene_variant; missense_variant; upstream_gene_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 22	chr22:0-50818468	2 (0/1/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr22:26521983..26596717 View in gBrowse