Gene Report

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Basic Info

Approved Symbol	LGI1
Previous Symbol	EPT
Symbol Alias	IB1099, ETL1, EPITEMPIN
Approved Name	leucine-rich, glioma inactivated 1
Previous Name	epilepsy, partial
Location	10q24
Position	chr10:93757809-93806272, 1
External Links	HGNC: 6572 Entrez Gene: 9211 Ensembl: ENSG00000108231 UCSC: uc001kjc.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fallin, M. D.,2005		5 SNP typed, Median D'=0.34, Median r<sup>2</sup> =0.04, 4 LD blocks, 0.02 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in SZ/SZA and all SNP or haplotype P-value > 0.05 in BP.. This gene is suggestive to SZ/SZA , not suggestive to BP.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0031175	neuron projection development	biological process	IMP[20463223]	10
GO:0007399	nervous system development	biological process	TAS[9879993]	40
GO:0007411	axon guidance	biological process	IMP[20463223]	60
GO:0005102	receptor binding	molecular function	IPI[20463223]; IPI[20463223]	37
GO:0045202	synapse	cellular component	IEA	29

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005615	extracellular space	cellular component	IDA[17067999]	85
GO:0030054	cell junction	cellular component	IEA	88
GO:0050806	positive regulation of synaptic transmission	biological process	ISS	4
GO:0051260	protein homooligomerization	biological process	IEA	13
GO:0030307	positive regulation of cell growth	biological process	IMP[20463223]	8
GO:0008283	cell proliferation	biological process	TAS[9879993]	37
GO:0005576	extracellular region	cellular component	IEA	97
GO:0005515	protein binding	molecular function	IPI[20463223]	563

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
LGI1	ADAM22	NO	in vitro	16990550

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
10q22.1-q24.1	chr10:68800000-97500000	1 (1/0/0)
10q23.3	chr10:87700000-95300000	1 (0/1/0)
10q22.3-24.1	chr10:75900000-97500000	1 (0/1/0)
Chr 10	chr10:0-133797422	3 (0/2/1)
10q23.33	chr10:92300000-95300000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16380905	This gene is suggestive to SZ/SZA , not suggestive to BP.	Trend

Reference	ID in SZGene	Result Category
16380905	177	Trend

Gene relationship with MDD

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Region: chr10:93757809..93806272 View in gBrowse