Gene Report

Basic Info
Approved Symbol SEZ6L
Approved Name seizure related 6 homolog (mouse)-like
Previous Name seizure related gene 6 (mouse)-like
Location 22q12.1
Position chr22:26169474-26383597, 1
External Links HGNC: 10763
Entrez Gene: 23544
Ensembl: ENSG00000100095
UCSC: uc003acb.3
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Xu, C.,2012 SNP: rs12485236, rs16981495, rs16981987, rs16981995, rs17305959, rs17306064, rs2144350, rs2331245, rs2847316, rs4822691, rs4822693, rs4822697, rs5761499, rs5997055, rs662329, rs7511475 This is the first demonstration that genetic variants in the SEZ6L gene are associated with BD-I in female patients and provides additional compelling evidence for genetic variation at 22q11-13 that influences BD-I risk. The present findings highlight the gene x gender interactions modifying BD-I susceptibility. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 7)

GO terms by PBA (count: 1)

GO terms by database search (count: 6)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 48)

Literature-origin SNPs (count: 16)

LD-proxies (count: 32)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

View in gBrowse

Region: chr22:26169474..26383597 View in gBrowse
View in gBrowse