Gene Report

Approved Symbol	SEZ6L
Approved Name	seizure related 6 homolog (mouse)-like
Previous Name	seizure related gene 6 (mouse)-like
Location	22q12.1
Position	chr22:26169474-26383597, 1
External Links	HGNC: 10763 Entrez Gene: 23544 Ensembl: ENSG00000100095 UCSC: uc003acb.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, C.,2012	SNP: rs12485236, rs16981495, rs16981987, rs16981995, rs17305959, rs17306064, rs2144350, rs2331245, rs2847316, rs4822691, rs4822693, rs4822697, rs5761499, rs5997055, rs662329, rs7511475	This is the first demonstration that genetic variants in the SEZ6L gene are associated with BD-I in female patients and provides additional compelling evidence for genetic variation at 22q11-13 that influences BD-I risk. The present findings highlight the gene x gender interactions modifying BD-I susceptibility.	Positive	Comment on Study

Region: chr22:26169474..26383597 View in gBrowse