Gene Report

Basic Info
Approved Symbol ATF5
Approved Name activating transcription factor 5
Location 19q13.33
Position chr19:49928702-49933935, 1
External Links HGNC: 790
Entrez Gene: 22809
Ensembl: ENSG00000169136
UCSC: uc002prd.3
No. of Studies 1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kakiuchi, C., 2007 (b) SNP: rs1152230, rs283524, rs283525, rs8647, rs8667
Haplotype: rs1152230 - rs283524(), rs1152230 - rs283524 - rs283525(), rs1152230 - rs283524 - rs283525 - rs8647(), rs1152230 - rs283524 - rs283525 - rs8647 - rs8667(), rs283524 - rs283525(), rs283524 - rs283525 - rs8647(), rs283524 - rs283525 - rs8647 - rs8667(), rs283525 - rs8647(), rs283525 - rs8647 - rs8667(), rs8647 - rs8667()
We did not find the association of ATF5 with bipolar disorder by genetic association study of Japanese samples and NIMH trio samples. In addition, there was no difference of mRNA expression levels between BPI patients and controls. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 18)

GO terms by PBA (count: 1)

GO terms by database search (count: 17)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Related other genetic factors
Gene related SNPs (count: 9)

Literature-origin SNPs (count: 5)

LD-proxies (count: 4)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr19:49928702..49933935 View in gBrowse
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