Gene Report

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Basic Info

Approved Symbol	SMCO1
Previous Symbol	C3orf43
Symbol Alias	FLJ41923, DKFZp313B0440
Approved Name	single-pass membrane protein with coiled-coil domains 1
Previous Name	chromosome 3 open reading frame 43
Location	3q29
Position	chr3:196506877-196515366, -1
External Links	HGNC: 27407 Entrez Gene: 255798 Ensembl: ENSG00000214097
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Schosser, A.,2011	SNP: rs2341399 Haplotype: rs6778889 - rs2341399(), rs6778889 - rs9311()	No significant association was observed.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6778889	chr3:196506924 - 196506924(1)	3_prime_UTR_variant; NMD_transcript_variant; upstream_gene_variant	1(0/1/0)
rs2341399	chr3:196520569 - 196520569(1)		1(0/1/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs6803596		chr3:196509373 - 196509373(1)	intron_variant; NMD_transcript_variant
rs11185544		chr3:196518732 - 196518732(1)	upstream_gene_variant

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Malhotra[2011]_2	chr3:197417247-198249463 (NCBI Build 36 (hg18))	832217	3q29	deletion	De Novo

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)
3q29	chr3:192600000-198295559	2 (1/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr3:196506877..196515366 View in gBrowse