Gene Report

Basic Info
Approved Symbol EGR3
Symbol Alias PILOT
Approved Name early growth response 3
Name Alias zinc finger protein pilot
Location 8p23-p21
Position chr8:22687659-22693302, -1
External Links HGNC: 3240
Entrez Gene: 1960
Ensembl: ENSG00000179388
UCSC: uc003xcm.1
No. of Studies 3 (Positive: 2; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Gallitano, A. L.,2012 SNP: rs1008949, rs10095121, rs10104039, rs11775096, rs17088536, rs1996147, rs2090052, rs3750192, rs4295666, rs4520160, rs4535741, rs4872533
Haplotype: rs10095121 - rs10104039(C-C), rs10095121 - rs10104039(C-T), rs10095121 - rs10104039(T-C), rs10095121 - rs10104039(T-T)
Our study revealed a preliminary finding suggesting that EGR3, a gene that translates environmental stimuli into long-term changes in the brain, warrants further investigation for association with risk for child BP-I disorder in a larger sample. Positive Comment on Study
Mansour, H. A.,2009 SNP: rs1996147 Gene-based tests:X<sup>2</sup>=7.248, P-value = 0.014 in recessive model, X<sup>2</sup>=7.659, P-value = 0.02 in additive model, X<sup>2</sup>=2.613, P-value = 0.288 in dominant model in BPI. Significant association was observed using both single SNP-based analyses and gene-based tests in BPI. Positive Comment on Study
Byrne, E. M., 2014 P-value=0.10. Gene-based tests show no significant association between this gene and BD. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 21)

GO terms by PBA (count: 3)

GO terms by database search (count: 18)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 13)

Literature-origin SNPs (count: 12)

LD-proxies (count: 1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 2)

Overlap with SZ from candidate gene intersection analysis (count: 5)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr8:22687659..22693302 View in gBrowse
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