Gene Report

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Basic Info

Approved Symbol	FST
Symbol Alias	FS
Approved Name	follistatin
Location	5q11.2
Position	chr5:53480409-53487134, 1
External Links	HGNC: 3971 Entrez Gene: 10468 Ensembl: ENSG00000134363 UCSC: uc003jpd.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Smith, E. N.,2011	SNP: rs7703177	Suggestive association of this gene was found.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IEA	283
GO:0004871	signal transducer activity	molecular function	NAS[12702211]	32

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0051798	positive regulation of hair follicle development	biological process	IDA[12514121]	2
GO:0045596	negative regulation of cell differentiation	biological process	IEA	2
GO:0008585	female gonad development	biological process	IEA	2
GO:0043395	heparan sulfate proteoglycan binding	molecular function	IEA	3
GO:0042475	odontogenesis of dentin-containing tooth	biological process	IEA	8
GO:0005576	extracellular region	cellular component	TAS	97
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0007389	pattern specification process	biological process	IEA	4
GO:0048185	activin binding	molecular function	IPI[12697670]	1
GO:0030509	BMP signaling pathway	biological process	IEA	6
GO:0005515	protein binding	molecular function	IPI[16198295]	563
GO:0001501	skeletal system development	biological process	IEA	16
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[12702211]	62
GO:0031069	hair follicle morphogenesis	biological process	IEA	4
GO:0032926	negative regulation of activin receptor signaling pathway	biological process	IDA[11948405]	2
GO:0002244	hematopoietic progenitor cell differentiation	biological process	IDA[15451575]	6
GO:0007276	gamete generation	biological process	IEA	1
GO:0043616	keratinocyte proliferation	biological process	IEA	4

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04350	TGF-beta signaling pathway	10

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
FST	INHA	NO	in vivo	2036994
FST	INHBA	NO	in vitro	7887917
FST	INHBE	NO	in vitro	12242034
FST	BMP5	NO	in vivo	11580864
FST	FN1	NO	in vitro	16336961

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs7703177	chr5:53503626 - 53503626(1)		1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 5	chr5:0-181538259	3 (0/2/1)
5p13.1-5q12.3	chr5:38400000-67400000	1 (0/1/0)
5p13.3-q13.3	chr5:28900000-77600000	1 (1/0/0)
5q11	chr5:48800000-59600000	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr5:53480409..53487134 View in gBrowse