BDgene

Gene Report

Basic Info
Approved Symbol LEPR
Symbol Alias OBR, CD295
Approved Name leptin receptor
Location 1p31
Position chr1:65420652-65641559, 1
External Links HGNC: 6554
Entrez Gene: 3953
Ensembl: ENSG00000116678
UCSC: uc001dci.3
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Gratacos, M.,2009 SNP: rs9436299
Other variant: LEPR_hcv518168
Nominal associations with bipolar disorder was observed. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 15)

GO terms by PBA (count: 4)

GO terms by database search (count: 11)


Gene related KEGG pathways (count: 4)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 3)


Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)


Gene related interactors from protein-protein interactions data in HPRD (count: 12)

Related other genetic factors
Gene related SNPs (count: 23)

Literature-origin SNPs (count: 1)

LD-proxies (count: 22)


Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 2)


View in gBrowse

Region: chr1:65420652..65641559 View in gBrowse
View in gBrowse