Gene Report

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Basic Info

Approved Symbol	ZNF490
Symbol Alias	KIAA1198
Approved Name	zinc finger protein 490
Location	19p13.2
Position	chr19:12577961-12640098, -1
External Links	HGNC: 23705 Entrez Gene: 57474 Ensembl: ENSG00000188033 UCSC: uc002mtz.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BP:Smallest P-value per gene=0.00002, Product of P truncation <=0.01=0.00025, Product of P truncation <=0.001=0.00011. It showed evidence for association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IBA	66
GO:0005634	nucleus	cellular component	IEA	283
GO:0003677	DNA binding	molecular function	IEA	83

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0005515	protein binding	molecular function	IPI[21516116]	563
GO:0006355	regulation of transcription, DNA-templated	biological process	IBA	62

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs7247513	chr19:12580371 - 12580371(1)	3_prime_UTR_variant; downstream_gene_variant; NMD_transcript_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
19p13-q13	chr19:0-58617616	1 (0/1/0)
Chr 19	chr19:0-58617616	2 (0/2/0)
19p13	chr19:0-19900000	2 (0/1/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	It showed no evidence for association with SZ.	Negative

Reference	ID in SZGene	Result Category
11204350	203	Negative

Gene relationship with MDD

View in gBrowse

Region: chr19:12577961..12640098 View in gBrowse