Gene Report

Basic Info
Approved Symbol ABCA13
Symbol Alias FLJ33876, FLJ33951
Approved Name ATP-binding cassette, sub-family A (ABC1), member 13
Location 7p12.3
Position chr7:48171458-48647496, 1
External Links HGNC: 14638
Entrez Gene: 154664
Ensembl: ENSG00000179869
UCSC: uc003toq.2
No. of Studies 2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Knight, H. M.,2009 Other variant: ABCA13_exon33_H3609P, ABCA13_exon52_R4590W, ABCA13_exon54_R4728X, ABCA13_exon57_R4843C, ABCA13_exon40_T4031A, ABCA13_exon52_T4550A The frequency of all rare variants combined was greater than controls in schizophrenia (OR=1.93, P-value = 0.0057) and bipolar disorder (OR=2.71, P-value = 0.00007).These data identify a candidate gene, highlight the genetic overlap between schizophrenia, bipolar disorder, and depression, and suggest that rare coding variants may contribute significantly to risk of these disorders. Positive Comment on Study
Chen, X., 2015 ABCA13 has been implicated in SCZ, BPD, depression and autism. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 10)

GO terms by PBA (count: 1)

GO terms by database search (count: 9)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 6)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr7:48171458..48647496 View in gBrowse
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