Gene Report

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Basic Info

Approved Symbol	STEAP3
Symbol Alias	TSAP6, dudlin-2, STMP3
Approved Name	STEAP family member 3, metalloreductase
Location	2q14.2
Position	chr2:119223831-119265652, 1
External Links	HGNC: 24592 Entrez Gene: 55240 Ensembl: ENSG00000115107 UCSC: uc002tlr.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gonzalez, S., 2014	SNP: rs708670, rs895406	It showed nominal evidence for association with BD.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005887	integral component of plasma membrane	cellular component	IBA	158

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008823	cupric reductase activity	molecular function	IBA	1
GO:0010008	endosome membrane	cellular component	TAS	17
GO:0006879	cellular iron ion homeostasis	biological process	TAS	7
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0005515	protein binding	molecular function	IPI[22624035]	563
GO:1902167	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	biological process	IEA	1
GO:0000293	ferric-chelate reductase activity	molecular function	IEA	1
GO:0005771	multivesicular body	cellular component	IDA[15319436]	4
GO:0097461	ferric iron import into cell	biological process	IBA	1
GO:1990182	exosomal secretion	biological process	IEA	1
GO:0055114	oxidation-reduction process	biological process	IBA	43
GO:0052851	ferric-chelate reductase (NADPH) activity	molecular function	IBA	1
GO:0006915	apoptotic process	biological process	IEA	39
GO:0055085	transmembrane transport	biological process	TAS	77
GO:0009306	protein secretion	biological process	IDA[15319436]; IMP[22624035]	3
GO:0007049	cell cycle	biological process	IEA	6
GO:0015677	copper ion import	biological process	IBA	1
GO:0033572	transferrin transport	biological process	TAS	7

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04115	p53 signaling pathway	4

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
STEAP3	TPT1	NO	in vitro;yeast 2-hybrid	15319436
STEAP3	BNIP3L	YES	in vitro;in vivo;yeast 2-hybrid	12606722
STEAP3	PKMYT1	NO	in vitro;in vivo;yeast 2-hybrid	12606722

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs708670	chr2:119229661 - 119229661(1)	intron_variant	1(0/0/1)
rs895406	chr2:119251644 - 119251644(1)	intron_variant; upstream_gene_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2q12.3-q22.1	chr2:106700000-141500000	1 (0/1/0)
Chr 2	chr2:0-242193529	3 (0/3/0)
2p11-q14	chr2:83100000-129100000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:119223831..119265652 View in gBrowse