Gene Report

Approved Symbol	PDLIM5
Symbol Alias	LIM, Enh
Approved Name	PDZ and LIM domain 5
Location	4q22
Position	chr4:94451857-94668227, 1
External Links	HGNC: 17468 Entrez Gene: 10611 Ensembl: ENSG00000163110 UCSC: uc003htk.4
No. of Studies	5 (Positive: 4; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Zain, M. A., 2013	SNP: rs7690296, rs11097431	Therefore, it can be deduced that the nonsynonymous rs7690296 polymorphism could play an important role in the pathophysiology of both bipolar disorder and schizophrenia.	Positive	Comment on Study
Squassina, A.,2008	SNP: rs10008257, rs2433320, rs2433322 Haplotype: rs10008257 - rs2433320(), rs10008257 - rs2433320(A-A), rs10008257 - rs2433320(A-G), rs10008257 - rs2433320(G-A), rs10008257 - rs2433320(G-G ), rs10008257 - rs2433320 - rs2433322(), rs10008257 - rs2433320 - rs2433322(A-A-G), rs10008257 - rs2433320 - rs2433322(A-G-A), rs10008257 - rs2433320 - rs2433322(G-A-G), rs10008257 - rs2433320 - rs2433322(G-G-A), rs2433320 - rs2433322(), rs2433320 - rs2433322(A-G), rs2433320 - rs2433322(G-A)	In single-marker analysis, no association was found for any of the SNPs tested. After correction for multiple testing, haplotype analysis showed slight statistically significant association for a rare haplotype of SNPs 1 and 2, P-value = 0.009; corrected P-value = 0.040 . Although the findings presented in this paper do not provide strong evidence that the PDLIM5 gene significantly affects the pathophysiology of BD, they suggest that rare variants within the promoter region of the gene may have a marginal effect on the disorder.	Positive	Comment on Study
Yosifova, A.,2009	SNP: rs10008257, rs2438146	No SNP of this gene had significant association with BD in our population.	Negative	Comment on Study
Shi, J., 2008 (c)	SNP: rs10008257, rs1543013, rs2433320, rs2452594, rs774992 Haplotype: rs10008257 - rs2433320(GA), rs10008257 - rs2433320(GG), rs10008257 - rs2433320(AG), rs10008257 - rs2433320(AA), rs2452594 - rs1543013(GA), rs2452594 - rs1543013(AC), rs2452594 - rs1543013(GC)	The meta-analysis identified a significant allelic association at rs2433320 in all combined samples (excluding overlapped samples in GWA: overall OR = 0.897, 95% CI: 0.838-0.961, adjusted p = 0.012) and in all Caucasian samples (excluding overlapped samples in GWA: overall OR = 0.905, 95% CI: 0.843-0.971, adjusted p = 0.032), but not in the Japanese samples.. PDLIM5 may play a minor effect on susceptibility to bipolar disorder in Caucasians.	Positive	Comment on Study
Zhao, T.,2009	SNP: rs10008257, rs2433320, rs2433322, rs2438146 Haplotype: rs10008257 - rs2433320(), rs10008257 - rs2433320 - rs2433322(A-A-G), rs10008257 - rs2433320 - rs2433322(G-G-A), rs10008257 - rs2433320 - rs2433322(G-G-G), rs10008257 - rs2433320 - rs2433322 - rs2438146(A-A-G-T), rs2433320 - rs2433322(A-A), rs2433320 - rs2433322(G-A), rs2433320 - rs2433322(G-G), rs2433320 - rs2433322 - rs2438146(G-A-C), rs2433320 - rs2433322 - rs2438146(G-G-C), rs2433322 - rs2438146(A-C), rs2433322 - rs2438146(G-C)	In conclusion, our case-control study provided consistent evidence that PDLIM5 might play a potential role in the susceptibility to bipolar disorder in the Chinese Han population.	Positive	Comment on Study

Region: chr4:94451857..94668227 View in gBrowse