Gene Report

Basic Info
Approved Symbol CHRNB4
Approved Name cholinergic receptor, nicotinic, beta 4 (neuronal)
Previous Name cholinergic receptor, nicotinic, beta polypeptide 4
Name Alias acetylcholine receptor, nicotinic, beta 4 (neuronal)
Location 15q24
Position chr15:78624119-78727754, -1
External Links HGNC: 1964
Entrez Gene: 1143
Ensembl: ENSG00000117971
UCSC: uc002bed.1
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Shi, J., 2007 SNP: rs11633223, rs1316971, rs1948, rs7178270
Haplotype: rs1948 - rs7178270 - rs1316971 - rs11633223(G-C-G-G)
no evidence of interaction among these 19 cholinergic genes was found by Allelic Association, Haploview Tests, FITF analysis and FDR correction Negative Comment on Study
Jackson, K. J., 2013 SNP: rs17487223 Variants in the 15q25 gene cluster are associated with risk for schizophrenia/bipolar illness, negative symptoms of schizophrenia, and influence CHRNA5 expression in the brain and peripheral blood mononuclear cells. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 23)

GO terms by PBA (count: 7)

GO terms by database search (count: 16)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Related other genetic factors
Gene related SNPs (count: 13)

Literature-origin SNPs (count: 6)

LD-proxies (count: 7)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

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Region: chr15:78624119..78727754 View in gBrowse
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