BDgene

Gene Report

Basic Info
Approved Symbol ACE
Previous Symbol DCP1
Symbol Alias ACE1, CD143
Approved Name angiotensin I converting enzyme
Previous Name angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Name Alias peptidyl-dipeptidase A
Location 17q23.3
Position chr17:63477061-63498380, 1
External Links HGNC: 2707
Entrez Gene: 1636
Ensembl: ENSG00000159640
UCSC: uc002jau.2
No. of Studies 5 (Positive: 2; Negative: 3; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 5)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Mendlewicz, J.,2005 Other variant: ACE1_dbSNP4295 In conclusion, our findings do not support a major contribution of SP-related genes in UPAD and BPAD, but provides some evidence of an ACE influence in treatment response to antidepressants. Negative Comment on Study
Zou, Y. F.,2011 Other variant: ACE_insertion/deletion This meta-analysis suggests that there may be an association of ACE gene I/D polymorphism with BPD in Asians. Positive Comment on Study
Furlong, R. A.,2000 Other variant: ACE_insertion/deletion These results do not support the ACE gene having a major role in the etiology of either bipolar or unipolar affective disorders. Negative Comment on Study
Meira-Lima, I. V.,2000 Other variant: ACE_insertion/deletion The ACE I/D variant did not show any difference in allelic frequencies and genotypic distribution between the groups. Negative Comment on Study
Arinami, T.,1996 Other variant: ACE_insertion/deletion The D allele was significantly more frequent in the patients with bipolar affective disorders than in the controls, and the DD genotype was significantly more frequent in the patients with bipolar affective disorders than in the controls. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 51)

GO terms by PBA (count: 6)

GO terms by database search (count: 45)


Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)


Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)


Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

Gene related other variants (count: 2)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 8)


Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 2)

Overlap with MDD from candidate gene intersection analysis (count: 6)


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Region: chr17:63477061..63498380 View in gBrowse
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