Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	THSD7A
Symbol Alias	KIAA0960
Approved Name	thrombospondin, type I, domain containing 7A
Location	7p21.3
Position	chr7:11370357-11832198, -1
External Links	HGNC: 22207 Entrez Gene: 221981 Ensembl: ENSG00000005108 UCSC: uc032zeh.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BP:Smallest P-value per gene=0.02421, Product of P truncation <=0.01=0.00032, Product of P truncation <=0.001=0.00425. It showed evidence for association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030154	cell differentiation	biological process	IEA	31
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0005886	plasma membrane	cellular component	IEA	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0001525	angiogenesis	biological process	IEA	20

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs10277665	chr7:11519953 - 11519953(1)	intron_variant; non_coding_transcript_variant	1(1/0/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7p22.2-p21.1	chr7:2800000-20900000	1 (0/0/1)
Chr 7	chr7:0-159345973	3 (0/3/0)
7p21.3	chr7:7200000-13700000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	It showed no evidence for association with SZ.	Negative

Gene relationship with MDD

View in gBrowse

Region: chr7:11370357..11832198 View in gBrowse