Gene Report

Basic Info
Approved Symbol RUVBL2
Symbol Alias RVB2, TIP48, TIP49b, Reptin52, ECP51, TIH2, INO80J, Rvb2
Approved Name RuvB-like AAA ATPase 2
Previous Name RuvB (E coli homolog)-like 2, "RuvB-like 2 (E. coli)"
Name Alias reptin, "INO80 complex subunit J"
Location 19q13.3
Position chr19:48993448-49015995, 1
External Links HGNC: 10475
Entrez Gene: 10856
Ensembl: ENSG00000183207
UCSC: uc002plr.1
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Drago, A., 2016 Freq(Significant SNPs/total SNPs%)=0.08. This gene encodes the second human homolog of the bacterial RuvB gene, a DNA helicase. Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 42)

GO terms by PBA (count: 2)

GO terms by database search (count: 40)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 2)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 11)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr19:48993448..49015995 View in gBrowse
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