Gene Report

Basic Info
Approved Symbol PPP3CB
Previous Symbol CALNB
Symbol Alias CALNA2, CNA2, PP2Bbeta
Approved Name protein phosphatase 3, catalytic subunit, beta isozyme
Previous Name protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta), "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform"
Name Alias calcineurin A beta, "protein phosphatase 2B, catalytic subunit, beta isoform"
Location 10q22.2
Position chr10:73436428-73496024, -1
External Links HGNC: 9315
Entrez Gene: 5532
Ensembl: ENSG00000107758
UCSC: uc001juf.3
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Fallin, M. D.,2005 3 SNP typed, Median D'=1, Median r<sup>2</sup> =0.77, 1 LD blocks, 0.64 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. Negative Comment on Study
Forero, D. A., 2016 SNP: rs12775630, rs3793663 P-value=0.005. HapMap based haplotype block analysis as well as sliding window haplotype analysis revealed significant associations with NF1 (p=0,01), PPP3CB (p=0005) and PRKAR1A (p=0,03) in the total BP and SZ samples. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 42)

GO terms by PBA (count: 4)

GO terms by database search (count: 38)

Gene related KEGG pathways (count: 10)

Gene related BioCarta pathways (count: 12)

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Related other genetic factors
Gene related SNPs (count: 13)

Literature-origin SNPs (count: 2)

LD-proxies (count: 11)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

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Region: chr10:73436428..73496024 View in gBrowse
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