Gene Report

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Basic Info

Approved Symbol	NUF2
Previous Symbol	CDCA1
Symbol Alias	NUF2R, CT106
Approved Name	NUF2, NDC80 kinetochore complex component
Previous Name	cell division cycle associated 1, "NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)"
Name Alias	cancer/testis antigen 106
Location	1q23.3
Position	chr1:163266576-163355764, 1
External Links	HGNC: 14621 Entrez Gene: 83540 Ensembl: ENSG00000143228 UCSC: uc001gcr.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0053. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IEA	283
GO:0016020	membrane	cellular component	IDA[19946888]	137

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005829	cytosol	cellular component	TAS	223
GO:0005515	protein binding	molecular function	IPI[14699129]	563
GO:0051301	cell division	biological process	IEA	20
GO:0000775	chromosome, centromeric region	cellular component	NAS[11266451]	2
GO:0000278	mitotic cell cycle	biological process	TAS	33
GO:0031262	Ndc80 complex	cellular component	IDA[14699129]	1
GO:0007059	chromosome segregation	biological process	NAS[11266451]	2
GO:0007067	mitotic nuclear division	biological process	IEA	15
GO:0000777	condensed chromosome kinetochore	cellular component	IEA	7
GO:0003674	molecular_function	molecular function	ND	24

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NUF2	NDC80	NO	yeast 2-hybrid	14602875
NUF2	ATF3	NO	yeast 2-hybrid	16169070
NUF2	AURKA	NO	in vitro;in vivo	14602875

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1q23	chr1:156600000-165500000	1 (0/1/0)
1p32.1-q31.1	chr1:58500000-190800000	1 (0/1/0)
1q23.3	chr1:160500000-165500000	1 (0/0/1)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr1:163266576..163355764 View in gBrowse