Gene Report

Approved Symbol	NPAS3
Symbol Alias	MOP6, PASD6, bHLHe12
Approved Name	neuronal PAS domain protein 3
Location	14q13.1
Position	chr14:32934933-33804176, 1
External Links	HGNC: 19311 Entrez Gene: 64067 Ensembl: ENSG00000151322 UCSC: uc001wru.3
No. of Studies	2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Pickard, B. S.,2009	SNP: rs1041128, rs1124910, rs1279210, rs1279214, rs1279338, rs1299512, rs1315141, rs1315142, rs1315151, rs1315158, rs1440199, rs1440201, rs1475067, rs173383, rs1886781, rs1886782, rs1952075, rs1952079, rs1952157, rs1952161, rs1952162, rs1952302, rs1952603, rs1953432, rs1953447, rs1956002, rs1957317, rs1958022, rs1958035, rs1958050, rs1958057, rs1958059, rs1958547, rs1959181, rs2077841, rs2144600, rs2183276, rs2383420, rs243287, rs243291, rs243301, rs243310, rs2891232, rs3949783, rs4128599, rs4143873, rs4982060, rs4982109, rs6571608, rs7141245, rs7152665, rs7157101, rs7158891, rs716193, rs719017, rs727447, rs729217, rs729231, rs733314, rs753239, rs8004477, rs8014172, rs8017303, rs8018440, rs878989, rs912857, rs927328, rs943164, rs944086, rs956884 Haplotype: rs173383 - rs243310 - rs1886782(G-T-A), rs729217 - rs7141245(A-T)	The presence of both risk and protective haplotypes at each of these four regions indicated locus and allelic heterogeneity within NPAS3 and suggested a model whereby interactions between variants across the gene might contribute to susceptibility to illness.	Positive	Comment on Study
Huang, J.,2010	SNP: rs4982029	No significant association of this gene was observed in BD.	Negative	Comment on Study

Region: chr14:32934933..33804176 View in gBrowse