Gene Report

Basic Info
Approved Symbol NPAS3
Symbol Alias MOP6, PASD6, bHLHe12
Approved Name neuronal PAS domain protein 3
Location 14q13.1
Position chr14:32934933-33804176, 1
External Links HGNC: 19311
Entrez Gene: 64067
Ensembl: ENSG00000151322
UCSC: uc001wru.3
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Pickard, B. S.,2009 SNP: rs1041128, rs1124910, rs1279210, rs1279214, rs1279338, rs1299512, rs1315141, rs1315142, rs1315151, rs1315158, rs1440199, rs1440201, rs1475067, rs173383, rs1886781, rs1886782, rs1952075, rs1952079, rs1952157, rs1952161, rs1952162, rs1952302, rs1952603, rs1953432, rs1953447, rs1956002, rs1957317, rs1958022, rs1958035, rs1958050, rs1958057, rs1958059, rs1958547, rs1959181, rs2077841, rs2144600, rs2183276, rs2383420, rs243287, rs243291, rs243301, rs243310, rs2891232, rs3949783, rs4128599, rs4143873, rs4982060, rs4982109, rs6571608, rs7141245, rs7152665, rs7157101, rs7158891, rs716193, rs719017, rs727447, rs729217, rs729231, rs733314, rs753239, rs8004477, rs8014172, rs8017303, rs8018440, rs878989, rs912857, rs927328, rs943164, rs944086, rs956884
Haplotype: rs173383 - rs243310 - rs1886782(G-T-A), rs729217 - rs7141245(A-T)
The presence of both risk and protective haplotypes at each of these four regions indicated locus and allelic heterogeneity within NPAS3 and suggested a model whereby interactions between variants across the gene might contribute to susceptibility to illness. Positive Comment on Study
Huang, J.,2010 SNP: rs4982029 No significant association of this gene was observed in BD. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 11)

GO terms by PBA (count: 2)

GO terms by database search (count: 9)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 259)

Literature-origin SNPs (count: 71)

LD-proxies (count: 188)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 7)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 2)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr14:32934933..33804176 View in gBrowse
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