Gene Report

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Basic Info

Approved Symbol	ANO3
Previous Symbol	C11orf25, TMEM16C
Symbol Alias	GENX-3947, DYT23
Approved Name	anoctamin 3
Previous Name	chromosome 11 open reading frame 25, "transmembrane protein 16C"
Name Alias	transmembrane protein 16C (eight membrane-spanning domains)
Location	11p14.2
Position	chr11:26309599-26663288, 1
External Links	HGNC: 14004 Entrez Gene: 63982 Ensembl: ENSG00000134343 UCSC: uc001mqt.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0010. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006869	lipid transport	biological process	IEA	4
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0005886	plasma membrane	cellular component	TAS	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0034220	ion transmembrane transport	biological process	TAS	50
GO:0005229	intracellular calcium activated chloride channel activity	molecular function	IDA[21984732]	3
GO:0061591	calcium activated galactosylceramide scrambling	biological process	IEA	1
GO:0055085	transmembrane transport	biological process	TAS	77
GO:0061590	calcium activated phosphatidylcholine scrambling	biological process	IEA	1
GO:0017128	phospholipid scramblase activity	molecular function	IEA	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 11	chr11:0-135086622	2 (0/2/0)
11q14.3-11q21	chr11:22000000-97400000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr11:26309599..26663288 View in gBrowse