Gene Report

Basic Info
Approved Symbol GNAZ
Approved Name guanine nucleotide binding protein (G protein), alpha z polypeptide
Location 22q11.1-q11.2
Position chr22:23070361-23125037, 1
External Links HGNC: 4395
Entrez Gene: 2781
Ensembl: ENSG00000128266
UCSC: uc002zwu.1
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Saito, T.,1999 Other variant: GNAZ_exon2_309C/T These data continue to provide some support for a BPD susceptibility gene on 22q11, possibly in linkage disequilibrium with the GNAZ 309 polymorphism. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 18)

GO terms by PBA (count: 2)

GO terms by database search (count: 16)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 14)

Related other genetic factors
Gene related SNPs (count: 37)

Literature-origin SNPs (count: 0)

LD-proxies (count: 37)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr22:23070361..23125037 View in gBrowse
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