Gene Report

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Basic Info

Approved Symbol	TCF7L1
Previous Symbol	TCF3
Approved Name	transcription factor 7-like 1 (T-cell specific, HMG-box)
Location	2p11.2
Position	chr2:85133410-85310388, 1
External Links	HGNC: 11640 Entrez Gene: 83439 Ensembl: ENSG00000152284 UCSC: uc002soy.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Ollila, H. M.,2009	SNP: rs6732834	It showed no evidence for association with BPI in our study.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0043565	sequence-specific DNA binding	molecular function	IBA	29
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	NAS[11085512]	66
GO:0003677	DNA binding	molecular function	NAS[11085512]	83
GO:0005634	nucleus	cellular component	NAS[11085512]	283
GO:0007420	brain development	biological process	IBA	25

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008013	beta-catenin binding	molecular function	IBA	14
GO:0035019	somatic stem cell maintenance	biological process	IEA	6
GO:0048319	axial mesoderm morphogenesis	biological process	IEA	1
GO:0043588	skin development	biological process	IEA	3
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0006325	chromatin organization	biological process	NAS[11085512]	14
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological process	IBA	21
GO:0006355	regulation of transcription, DNA-templated	biological process	NAS[11085512]	62
GO:0005654	nucleoplasm	cellular component	TAS	163
GO:0045892	negative regulation of transcription, DNA-templated	biological process	IEA	43
GO:0003682	chromatin binding	molecular function	IBA	23
GO:2000036	regulation of stem cell maintenance	biological process	IEA	1
GO:0048699	generation of neurons	biological process	IBA	3
GO:0044212	transcription regulatory region DNA binding	molecular function	IBA	17
GO:0005667	transcription factor complex	cellular component	IBA	18
GO:0060070	canonical Wnt signaling pathway	biological process	IBA	9
GO:0046022	positive regulation of transcription from RNA polymerase II promoter during mitosis	biological process	IEA	1
GO:0008595	anterior/posterior axis specification, embryo	biological process	IEA	1
GO:0030111	regulation of Wnt signaling pathway	biological process	NAS[11085512]	1

Gene related KEGG pathways (count: 9)

ID	Name	No. of Genes in BDgene	Brief Description
hsa05217	Basal cell carcinoma	8
hsa05221	Acute myeloid leukemia	7

ID	Name	No. of Genes in BDgene
hsa05210	Colorectal cancer	14
hsa04520	Adherens junction	11
hsa05213	Endometrial cancer	10
hsa05215	Prostate cancer	18
hsa05216	Thyroid cancer	4
hsa04310	Wnt signaling pathway	20
hsa04916	Melanogenesis	16

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TCF7L1	CTNNB1	NO	in vivo	11266540

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6732834	chr2:85278479 - 85278479(1)	intron_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2p16.1-q11.2	chr2:54700000-102100000	1 (1/0/0)
2p16.2-p11.2	chr2:52600000-91800000	1 (1/0/0)
Chr 2	chr2:0-242193529	3 (0/3/0)
2p11-q14	chr2:83100000-129100000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:85133410..85310388 View in gBrowse