Gene Report

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Basic Info

Approved Symbol	ADAM12
Symbol Alias	MCMPMltna, MLTN
Approved Name	ADAM metallopeptidase domain 12
Previous Name	a disintegrin and metalloproteinase domain 12 (meltrin alpha)
Name Alias	meltrin alpha
Location	10q26
Position	chr10:126012381-126388455, -1
External Links	HGNC: 190 Entrez Gene: 8038 Ensembl: ENSG00000148848 UCSC: uc031wwt.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0081. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007155	cell adhesion	biological process	IEA	42
GO:0005886	plasma membrane	cellular component	IDA	360
GO:0008237	metallopeptidase activity	molecular function	TAS[9417060]	8
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0004222	metalloendopeptidase activity	molecular function	IEA	8

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006508	proteolysis	biological process	IEA	34
GO:0007520	myoblast fusion	biological process	TAS[7566181]	4
GO:0005515	protein binding	molecular function	IPI[15574124]	563
GO:0007173	epidermal growth factor receptor signaling pathway	biological process	TAS	22
GO:0005576	extracellular region	cellular component	IEA	97
GO:0005739	mitochondrion	cellular component	IDA	75
GO:0017124	SH3 domain binding	molecular function	IPI[15280379]	11
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0008270	zinc ion binding	molecular function	IEA	77

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
cardiacegfPathway	Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy	5

Gene related interactors from protein-protein interactions data in HPRD (count: 11)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ADAM12	YES1	NO	in vitro;in vivo	11127814
ADAM12	IGFBP5	NO	in vitro	11095942
ADAM12	PACSIN3	NO	in vitro;in vivo;yeast 2-hybrid	12952982
ADAM12	EGF	NO	in vivo	11786904
ADAM12	FSTL3	NO	in vitro;in vivo;yeast 2-hybrid	15574124
ADAM12	IGFBP3	NO	in vitro;in vivo;yeast 2-hybrid	10849447
ADAM12	GRB2	NO	in vivo	11127814
ADAM12	SRC	NO	in vitro;in vivo	11127814
ADAM12	ACTN2	NO	in vitro;in vivo	10788519
ADAM12	SH3D19	NO	in vitro;in vivo;yeast 2-hybrid	15280379
ADAM12	PIK3R1	YES	in vitro;in vivo	11313349

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 10	chr10:0-133797422	3 (0/2/1)
10q25-q26	chr10:104000000-133797422	2 (0/0/2)
10q26	chr10:117300000-133797422	3 (0/1/2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	ID in SZGene	Result Category
18813210	745	Positive

Gene relationship with MDD

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Region: chr10:126012381..126388455 View in gBrowse