Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	TBXAS1
Symbol Alias	CYP5, CYP5A1, THAS, TXS, TXAS, TS
Approved Name	thromboxane A synthase 1 (platelet)
Previous Name	thromboxane A synthase 1 (platelet, cytochrome P450, subfamily V)
Name Alias	cytochrome P450, family 5, subfamily A, polypeptide 1
Location	7q34-q35
Position	chr7:139777051-140020325, 1
External Links	HGNC: 11609 Entrez Gene: 6916 Ensembl: ENSG00000059377 UCSC: uc003vvi.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs17161272	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0004497	monooxygenase activity	molecular function	IEA	1

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0019369	arachidonic acid metabolic process	biological process	TAS	2
GO:0019371	cyclooxygenase pathway	biological process	TAS	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular function	IEA	1
GO:0055114	oxidation-reduction process	biological process	IEA	43
GO:0020037	heme binding	molecular function	IEA	6
GO:0030644	cellular chloride ion homeostasis	biological process	IEA	1
GO:0006805	xenobiotic metabolic process	biological process	TAS	19
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0005506	iron ion binding	molecular function	IEA	8
GO:0006690	icosanoid metabolic process	biological process	TAS	1
GO:0005789	endoplasmic reticulum membrane	cellular component	TAS	52
GO:0004796	thromboxane-A synthase activity	molecular function	IEA	1
GO:0045907	positive regulation of vasoconstriction	biological process	IEA	12

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00590	Arachidonic acid metabolism	7

Gene related BioCarta pathways (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
sppaPathway	Aspirin Blocks Signaling Pathway Involved in Platelet Activation	1
eicosanoidPathway	Eicosanoid Metabolism	1

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs17161272	chr7:139936819 - 139936819(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs2158667		chr7:139938175 - 139938175(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 7	chr7:0-159345973	3 (0/3/0)
7q34	chr7:138500000-143400000	4 (2/0/2)
7q34-qter	chr7:138500000-159345973	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr7:139777051..140020325 View in gBrowse