Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	TAOK2
Symbol Alias	TAO1, KIAA0881, PSK, PSK1, TAO2, MAP3K17
Approved Name	TAO kinase 2
Location	16p11.2
Position	chr16:29973641-29992261, 1
External Links	HGNC: 16835 Entrez Gene: 9344 Ensembl: ENSG00000149930 UCSC: uc002dva.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Steinberg, S.,2012	SNP: rs4583255	No significant association was observed.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 28)

GO terms by PBA (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004674	protein serine/threonine kinase activity	molecular function	IDA[10660600]	27
GO:0005634	nucleus	cellular component	IDA	283
GO:0043235	receptor complex	cellular component	IDA[23382219]	20
GO:0016021	integral component of membrane	cellular component	IEA	219

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0031572	G2 DNA damage checkpoint	biological process	IMP[17396146]	2
GO:0031434	mitogen-activated protein kinase kinase binding	molecular function	IPI[11279118]	4
GO:0051403	stress-activated MAPK cascade	biological process	IDA[11279118]	8
GO:0006974	cellular response to DNA damage stimulus	biological process	IDA[17396146]	14
GO:0008360	regulation of cell shape	biological process	IDA[10660600]	16
GO:0006612	protein targeting to membrane	biological process	NAS[10660600]	2
GO:0030659	cytoplasmic vesicle membrane	cellular component	IEA	12
GO:0006468	protein phosphorylation	biological process	IEA	42
GO:0006915	apoptotic process	biological process	NAS[10660600]	39
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0005524	ATP binding	molecular function	IEA	118
GO:0005856	cytoskeleton	cellular component	IEA	30
GO:0006950	response to stress	biological process	IDA[10660600]	5
GO:0016023	cytoplasmic membrane-bounded vesicle	cellular component	IDA[10660600]	16
GO:0016477	cell migration	biological process	NAS[10660600]	17
GO:0030425	dendrite	cellular component	IEA	65
GO:0046330	positive regulation of JNK cascade	biological process	IDA[10660600]	4
GO:0001558	regulation of cell growth	biological process	NAS[10660600]	7
GO:0030036	actin cytoskeleton organization	biological process	IDA[10660600]	9
GO:0005730	nucleolus	cellular component	IDA	28
GO:0032874	positive regulation of stress-activated MAPK cascade	biological process	IMP[17396146]	2
GO:0048041	focal adhesion assembly	biological process	IDA[10660600]	4
GO:0004709	MAP kinase kinase kinase activity	molecular function	IBA	2
GO:0000186	activation of MAPKK activity	biological process	IDA[10660600]	6

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04010	MAPK signaling pathway	39

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 6)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TAOK2	MAP2K6	YES	in vitro;in vivo	11279118 , 10497253
TAOK2	TUBB	YES	in vitro	12639963
TAOK2	ELK1	NO	in vitro	12665513
TAOK2	MAP2K3	NO	in vitro;in vivo	11279118 , 10497253 , 9786855
TAOK2	TUBA4A	NO	in vitro	12639963
TAOK2	MEGF10	NO	yeast 2-hybrid	12421765

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4583255	chr16:29977620 - 29977620(1)	downstream_gene_variant; intron_variant; upstream_gene_variant	1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 9)

ID	Location	Size	Band	Type	Inheritance
CNV_Zhang[2009]_280	chr16:29425212-30099408 (Affymetrix SNP 6.0 array reference genome)	674196		Singleton deletions
CNV_Van Den Bossche[2012]_10	chr16:29678151-30135848 (hg19)	457697	16p11.2	duplication
CNV_Van Den Bossche[2012]_11	chr16:29678151-30135848 (hg19)	457697	16p11.2	duplication
CNV_Lyudmila Georgieva[2014]_10	chr16:29595483-30198151 (UCSC build 37, hg19)	602668	16p11.2	duplication
CNV_McCarthy[2009]_4	chr16:29559989-30085300 (NCBI Build 36 (hg18))	525312	16p11.2	duplication
CNV_McCarthy[2009]_3	chr16:29559989-30085300 (NCBI Build 36 (hg18))	525312	16p11.2	duplication
CNV_McCarthy[2009]_2	chr16:29559989-29926000 (NCBI Build 36 (hg18))	366012	16p11.2	duplication
CNV_McCarthy[2009]_1	chr16:29453358-30252310 (NCBI Build 36 (hg18))	798953	16p11.2	duplication
CNV_Malhotra[2011]_8	chr16:29512728-30124017 (NCBI Build 36 (hg18))	611290	16p11.2	duplication	De Novo

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 16	chr16:0-90338345	5 (1/3/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
23164818	Association results in schizophrenia follow-up samples(10,671 cases; 23,900 controls):OR(95% CI) = 1.06 (1.02, 1.10),P-value = 0.0011. No significant association was observed.	Negative

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

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Region: chr16:29973641..29992261 View in gBrowse