Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	ZAN
Approved Name	zonadhesin (gene/pseudogene)
Previous Name	zonadhesin
Location	7q22.1
Position	chr7:100733626-100797797, 1
External Links	HGNC: 12857 Entrez Gene: 7455 Ensembl: ENSG00000146839 UCSC: uc032zzh.1
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Georgi, B., 2014	SNP: rs10953303, rs482308, rs76325149, rs314299, rs314300 Other variant: ZAN_Chr7:100382373_C/T	Putative damaging exonic variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 4)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	NAS[9126492]	360
GO:0016021	integral component of membrane	cellular component	IEA	219

GO terms by database search (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016337	single organismal cell-cell adhesion	biological process	NAS[9126492]	10
GO:0007339	binding of sperm to zona pellucida	biological process	NAS[9126492]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 16)

Literature-origin SNPs (count: 5)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs10953303	chr7:100767990 - 100767990(1)	missense_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1(0/0/1)
rs314299	chr7:100773850 - 100773850(1)	missense_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1(0/0/1)
rs482308	chr7:100779751 - 100779751(1)	NMD_transcript_variant; non_coding_transcript_variant; splice_donor_variant	1(0/0/1)
rs314300	chr7:100776465 - 100776465(1)	missense_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1(0/0/1)
rs76325149	chr7:100791968 - 100791968(1)	missense_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; splice_region_variant	1(0/0/1)

LD-proxies (count: 11)

rs_ID	Location	Functional Annotation
rs10243399	chr7:100737232 - 100737232(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs489951	chr7:100773177 - 100773177(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs314344	chr7:100797381 - 100797381(1)	3_prime_UTR_variant; missense_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs314339	chr7:100793959 - 100793959(1)	intron_variant; missense_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; synonymous_variant
rs531503	chr7:100779460 - 100779460(1)	missense_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs314346	chr7:100800895 - 100800895(1)	downstream_gene_variant
rs539445	chr7:100775745 - 100775745(1)	missense_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs540330	chr7:100775649 - 100775649(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs2734880	chr7:100773477 - 100773477(1)	missense_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs314298	chr7:100773491 - 100773491(1)	missense_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; splice_region_variant
rs542137	chr7:100775455 - 100775455(1)	missense_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
ZAN_Chr7:100382373_C/T	point mutation	Chr7:100382373	1 (0/0/1)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7q21-31	chr7:77900000-127500000	1 (1/0/0)
7q22	chr7:98400000-107800000	1 (0/1/0)
Chr 7	chr7:0-159345973	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:100733626..100797797 View in gBrowse