Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	MAPK8IP2
Previous Symbol	PRKM8IPL
Symbol Alias	IB2, JIP2
Approved Name	mitogen-activated protein kinase 8 interacting protein 2
Previous Name	PRKM8 interacting protein-like
Name Alias	islet-brain 2, "JNK-interacting protein 2"
Location	22q13.33
Position	chr22:50600685-50613981, 1
External Links	HGNC: 6883 Entrez Gene: 23542 Ensembl: ENSG00000008735 UCSC: uc032qrw.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Severinsen, J. E., 2006 (b)	SNP: rs715519, rs916005 Haplotype: rs916005 - rs715519(), rs715519 - rs2272843(), rs715519 - rs2272843 - rs3810971(), rs715519 - rs2272843 - rs3810971 - rs137932(), rs916005 - rs715519 - rs2272843(), rs916005 - rs715519 - rs2272843 - rs3810971()	The results do not support an association of the gene with BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 28)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005198	structural molecule activity	molecular function	TAS[10490659]	14

GO terms by database search (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity	biological process	ISS	6
GO:0045860	positive regulation of protein kinase activity	biological process	IDA[12244047]; IGI[12244047]	8
GO:0010469	regulation of receptor activity	biological process	ISS	2
GO:0097481	neuronal postsynaptic density	cellular component	ISS	6
GO:0046328	regulation of JNK cascade	biological process	IDA[10490659]	2
GO:0030295	protein kinase activator activity	molecular function	IDA[12244047]; IGI[12244047]	2
GO:0019901	protein kinase binding	molecular function	IPI[10490659]	29
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	biological process	ISS	4
GO:0043025	neuronal cell body	cellular component	IEA	50
GO:0035176	social behavior	biological process	ISS	17
GO:0005078	MAP-kinase scaffold activity	molecular function	NAS[10490659]	1
GO:0048813	dendrite morphogenesis	biological process	ISS	5
GO:0019894	kinesin binding	molecular function	ISS	3
GO:0051966	regulation of synaptic transmission, glutamatergic	biological process	ISS	6
GO:0032874	positive regulation of stress-activated MAPK cascade	biological process	IEA	2
GO:0043234	protein complex	cellular component	IEA	27
GO:0001662	behavioral fear response	biological process	ISS	16
GO:0007254	JNK cascade	biological process	IEA	8
GO:0001540	beta-amyloid binding	molecular function	NAS[12023290]	4
GO:0060079	regulation of excitatory postsynaptic membrane potential	biological process	ISS	10
GO:0000165	MAPK cascade	biological process	IDA[12244047]	10
GO:0005737	cytoplasm	cellular component	IDA[10490659]	322
GO:0032403	protein complex binding	molecular function	IEA	16
GO:0007172	signal complex assembly	biological process	TAS[10490659]	2
GO:0005515	protein binding	molecular function	IPI[16273093]	563
GO:0007617	mating behavior	biological process	IEA	4
GO:0046958	nonassociative learning	biological process	ISS	1

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04010	MAPK signaling pathway	39

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 16)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
MAPK8IP2	MAP3K12	NO	in vivo	10490659
MAPK8IP2	KLC1	NO	in vivo;yeast 2-hybrid	12893827
MAPK8IP2	MAPK8IP1	YES	in vitro;in vivo	10490659 , 10629060
MAPK8IP2	PRSS23	NO	yeast 2-hybrid	16169070
MAPK8IP2	APP	NO	yeast 2-hybrid	12893827
MAPK8IP2	MAP3K11	NO	in vitro	10490659
MAPK8IP2	TIAM1	NO	in vivo	12024021
MAPK8IP2	DUSP16	NO	in vitro	12524447
MAPK8IP2	MAPK8IP3	NO	in vitro;in vivo	10629060
MAPK8IP2	MAP3K10	NO	in vivo	10490659
MAPK8IP2	LRP1	NO	in vitro;in vivo;yeast 2-hybrid	10827173
MAPK8IP2	LRP2	NO	in vitro;yeast 2-hybrid	10827173
MAPK8IP2	MAP2K7	NO	in vitro;in vivo	10756100 , 10490659
MAPK8IP2	MAPK8	NO	in vitro;in vivo	10756100 , 10490659
MAPK8IP2	MAPK9	NO	in vivo	10490659
MAPK8IP2	MAP2K3	NO	in vivo	12024021

Related other genetic factors

Gene related SNPs (count: 2)

Literature-origin SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs715519	chr22:50599940 - 50599940(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs916005	chr22:50605815 - 50605815(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 22	chr22:0-50818468	2 (0/1/1)
22q12.3-q13.33	chr22:31800000-50818468	1 (1/0/0)
22q13	chr22:37200000-50818468	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
16924267	The results do not support an association of the gene with SZ.	Negative

Overlap with SZ from candidate gene intersection analysis (count: 1)

Reference	ID in SZGene	Result Category
16924267	439	Negative

Gene relationship with MDD

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Region: chr22:50600685..50613981 View in gBrowse