Gene Report

Basic Info
Approved Symbol MAPK8IP2
Previous Symbol PRKM8IPL
Symbol Alias IB2, JIP2
Approved Name mitogen-activated protein kinase 8 interacting protein 2
Previous Name PRKM8 interacting protein-like
Name Alias islet-brain 2, "JNK-interacting protein 2"
Location 22q13.33
Position chr22:50600685-50613981, 1
External Links HGNC: 6883
Entrez Gene: 23542
Ensembl: ENSG00000008735
UCSC: uc032qrw.1
No. of Studies 1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Severinsen, J. E., 2006 (b) SNP: rs715519, rs916005
Haplotype: rs916005 - rs715519(), rs715519 - rs2272843(), rs715519 - rs2272843 - rs3810971(), rs715519 - rs2272843 - rs3810971 - rs137932(), rs916005 - rs715519 - rs2272843(), rs916005 - rs715519 - rs2272843 - rs3810971()
The results do not support an association of the gene with BD. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 28)

GO terms by PBA (count: 1)

GO terms by database search (count: 27)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 16)

Related other genetic factors
Gene related SNPs (count: 2)

Literature-origin SNPs (count: 2)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr22:50600685..50613981 View in gBrowse
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