Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	MAPK8IP2
Previous Symbol	PRKM8IPL
Symbol Alias	IB2, JIP2
Approved Name	mitogen-activated protein kinase 8 interacting protein 2
Previous Name	PRKM8 interacting protein-like
Name Alias	islet-brain 2, "JNK-interacting protein 2"
Location	22q13.33
Position	chr22:50600685-50613981, 1
External Links	HGNC: 6883 Entrez Gene: 23542 Ensembl: ENSG00000008735 UCSC: uc032qrw.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Severinsen, J. E., 2006 (b)	SNP: rs715519, rs916005 Haplotype: rs916005 - rs715519(), rs715519 - rs2272843(), rs715519 - rs2272843 - rs3810971(), rs715519 - rs2272843 - rs3810971 - rs137932(), rs916005 - rs715519 - rs2272843(), rs916005 - rs715519 - rs2272843 - rs3810971()	The results do not support an association of the gene with BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 28)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005198	structural molecule activity	molecular function	TAS[10490659]	14

GO terms by database search (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity	biological process	ISS	6
GO:0045860	positive regulation of protein kinase activity	biological process	IDA[12244047]; IGI[12244047]	8
GO:0010469	regulation of receptor activity	biological process	ISS	2
GO:0097481	neuronal postsynaptic density	cellular component	ISS	6
GO:0046328	regulation of JNK cascade	biological process	IDA[10490659]	2
GO:0030295	protein kinase activator activity	molecular function	IDA[12244047]; IGI[12244047]	2
GO:0019901	protein kinase binding	molecular function	IPI[10490659]	29
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	biological process	ISS	4
GO:0043025	neuronal cell body	cellular component	IEA	50
GO:0035176	social behavior	biological process	ISS	17
GO:0005078	MAP-kinase scaffold activity	molecular function	NAS[10490659]	1
GO:0048813	dendrite morphogenesis	biological process	ISS	5
GO:0019894	kinesin binding	molecular function	ISS	3
GO:0051966	regulation of synaptic transmission, glutamatergic	biological process	ISS	6
GO:0032874	positive regulation of stress-activated MAPK cascade	biological process	IEA	2
GO:0043234	protein complex	cellular component	IEA	27
GO:0001662	behavioral fear response	biological process	ISS	16
GO:0007254	JNK cascade	biological process	IEA	8
GO:0001540	beta-amyloid binding	molecular function	NAS[12023290]	4
GO:0060079	regulation of excitatory postsynaptic membrane potential	biological process	ISS	10
GO:0000165	MAPK cascade	biological process	IDA[12244047]	10
GO:0005737	cytoplasm	cellular component	IDA[10490659]	322
GO:0032403	protein complex binding	molecular function	IEA	16
GO:0007172	signal complex assembly	biological process	TAS[10490659]	2
GO:0005515	protein binding	molecular function	IPI[16273093]	563
GO:0007617	mating behavior	biological process	IEA	4
GO:0046958	nonassociative learning	biological process	ISS	1

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04010	MAPK signaling pathway	39

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 16)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
MAPK8IP2	TIAM1	NO	in vivo	12024021
MAPK8IP2	MAP3K10	NO	in vivo	10490659
MAPK8IP2	MAP2K3	NO	in vivo	12024021
MAPK8IP2	MAPK8IP1	YES	in vitro;in vivo	10490659 , 10629060
MAPK8IP2	MAP3K11	NO	in vitro	10490659
MAPK8IP2	KLC1	NO	in vivo;yeast 2-hybrid	12893827
MAPK8IP2	MAPK9	NO	in vivo	10490659
MAPK8IP2	LRP2	NO	in vitro;yeast 2-hybrid	10827173
MAPK8IP2	DUSP16	NO	in vitro	12524447
MAPK8IP2	APP	NO	yeast 2-hybrid	12893827
MAPK8IP2	PRSS23	NO	yeast 2-hybrid	16169070
MAPK8IP2	LRP1	NO	in vitro;in vivo;yeast 2-hybrid	10827173
MAPK8IP2	MAPK8	NO	in vitro;in vivo	10756100 , 10490659
MAPK8IP2	MAP2K7	NO	in vitro;in vivo	10756100 , 10490659
MAPK8IP2	MAPK8IP3	NO	in vitro;in vivo	10629060
MAPK8IP2	MAP3K12	NO	in vivo	10490659

Related other genetic factors

Gene related SNPs (count: 2)

Literature-origin SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs715519	chr22:50599940 - 50599940(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs916005	chr22:50605815 - 50605815(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 22	chr22:0-50818468	2 (0/1/1)
22q12.3-q13.33	chr22:31800000-50818468	1 (1/0/0)
22q13	chr22:37200000-50818468	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
16924267	The results do not support an association of the gene with SZ.	Negative

Overlap with SZ from candidate gene intersection analysis (count: 1)

Reference	ID in SZGene	Result Category
16924267	439	Negative

Gene relationship with MDD

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Region: chr22:50600685..50613981 View in gBrowse