Gene Report

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Basic Info

Approved Symbol	RGS17
Symbol Alias	RGSZ2, RGS-17
Approved Name	regulator of G-protein signaling 17
Previous Name	regulator of G-protein signalling 17
Location	6q25.2
Position	chr6:153004459-153131249, -1
External Links	HGNC: 14088 Entrez Gene: 26575 Ensembl: ENSG00000091844 UCSC: uc003qpm.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0011. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IEA	283
GO:0005886	plasma membrane	cellular component	IBA	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005737	cytoplasm	cellular component	IBA	322
GO:0043547	positive regulation of GTPase activity	biological process	IBA	30
GO:0005096	GTPase activator activity	molecular function	IBA	19
GO:0038032	termination of G-protein coupled receptor signaling pathway	biological process	IEA	7
GO:0005515	protein binding	molecular function	IPI[25416956]	563

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
RGS17	OSTM1	YES	yeast 2-hybrid	12826607

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q25.2	chr6:152100000-155200000	1 (0/1/0)
6q25	chr6:148500000-160600000	2 (0/1/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr6:153004459..153131249 View in gBrowse