BDgene

Core genes from gene prioritization

Reference:
1. Chang, S., Zhang, W., Gao, L. and Wang, J. (2012) Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources. Protein & Cell, 3, 526-534.
2. Serretti, A. and Mandelli, L. (2008) The genetics of bipolar disorder: genome 'hot regions,' genes, new potential candidates and future directions. Mol Psychiatry, 13, 742-771.


Training genes (count: 20)

Prioritized genes (count: 23)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend) SZ Correlation MDD Correlation Supported Tools All
DRD2 dopamine receptor D2 11q22-q23 28(8/20/0) YES YES DIR, Endeavour, ToppGene, ToppNet
DRD3 dopamine receptor D3 3q13.3 19(4/15/0) YES YES DIR, Endeavour, ToppGene
DRD4 dopamine receptor D4 11p15.5 13(1/12/0) YES YES DIR, Endeavour, ToppGene
CLOCK clock circadian regulator 4q12 12(5/7/0) YES YES Endeavour, ToppNet, TargetMine
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 15q13.3 4(2/2/0) YES YES Endeavour, ToppGene, TargetMine
MAOB monoamine oxidase B Xp11.4-p11.3 4(2/2/0) YES YES DIR, Endeavour, ToppGene
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 9q34.3 3(2/1/0) YES NO DIR, Endeavour, ToppGene, ToppNet
NCAM1 neural cell adhesion molecule 1 11q23.2 3(2/1/0) YES YES DIR, Endeavour, ToppNet
AKT1 v-akt murine thymoma viral oncogene homolog 1 14q32.33 3(3/0/0) YES NO DIR, ToppNet, TargetMine
GRM7 glutamate receptor, metabotropic 7 3p26-p25 3(2/1/0) YES NO DIR, Endeavour, ToppGene
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 9q22.1 3(1/1/1) YES YES DIR, Endeavour, ToppGene, ToppNet
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5q11.2-q13 3(2/1/0) YES YES Endeavour, ToppGene, TargetMine
ERBB4 erb-b2 receptor tyrosine kinase 4 2q33.3-q34 2(1/1/0) YES YES DIR, Endeavour, TargetMine
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 5q32 2(1/1/0) NO YES DIR, Endeavour, ToppNet, TargetMine
GRIA1 glutamate receptor, ionotropic, AMPA 1 5q33 2(2/0/0) YES YES DIR, Endeavour, ToppGene
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 10q21-q24 2(0/2/0) YES NO Endeavour, ToppGene, TargetMine
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 16p13.2 1(1/0/0) YES YES DIR, Endeavour, ToppGene
ESR1 estrogen receptor 1 6q24-q27 1(0/1/0) YES YES DIR, ToppGene, ToppNet
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 20q13.33 1(1/0/0) YES NO Endeavour, ToppGene, TargetMine
CHRM1 cholinergic receptor, muscarinic 1 11q12-q13 1(0/1/0) YES NO Endeavour, ToppGene, TargetMine
ADRB2 adrenoceptor beta 2, surface 5q31-q32 1(1/0/0) NO NO DIR, ToppGene, ToppNet, TargetMine
EGFR epidermal growth factor receptor 7p12 1(0/0/1) YES NO DIR, ToppGene, ToppNet, TargetMine
ADRA2A adrenoceptor alpha 2A 10q25.2 1(0/1/0) YES YES DIR, Endeavour, TargetMine