Core genes from gene prioritization
This part will provide a gene set from our gene prioritization analysis for all BD candidate genes in BDgene.
The gene prioritization is analyzed by using five multiple sources based
gene prioritization tools, including Endeavour,
ToppNet and TargetMine as what we did for ADHD in .
The training genes are from an extensively cited paper about hot genes of bipolar disorder  with one extra condition, that is the gene has at least three
positive results in BDgene. In addition, two recently found important genes from GWAS (ANK3 and CACNA1C) were also included.
The genes predicted by at least 3/5 tools were regarded as prioritized genes. Both training genes and prioritized genes were called 'core genes'.
1. Chang, S., Zhang, W., Gao, L. and Wang, J. (2012) Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources. Protein & Cell, 3, 526-534.
2. Serretti, A. and Mandelli, L. (2008) The genetics of bipolar disorder: genome 'hot regions,' genes, new potential candidates and future directions. Mol Psychiatry, 13, 742-771.
Enriched GO for Core Genes
Training genes (count: 20)
Prioritized genes (count: 23)