Gene Report

Approved Symbol	TRPM2
Previous Symbol	TRPC7
Symbol Alias	KNP3, LTRPC2, NUDT9L1, NUDT9H, EREG1
Approved Name	transient receptor potential cation channel, subfamily M, member 2
Location	21q22.3
Position	chr21:44350163-44443081, 1
External Links	HGNC: 12339 Entrez Gene: 7226 Ensembl: ENSG00000142185 UCSC: uc002zew.1
No. of Studies	5 (Positive: 3; Negative: 2; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Kostyrko, A., 2006	SNP: rs34601320, rs34803496, rs35698354 Other variant: TRPM2_c.2363C>T, TRPM2_c.2890+55A>G, TRPM2_c.3246+68C>T, TRPM2_c.3205C>T	Our findings do not support an association of the transitions in TRPM2 with the disorder, however, this study does not exclude TRPM2 as a candidate gene since we have screened only about 30 per cent of the entire coding sequence of this large gene.	Negative	Comment on Study
Roche, S., 2007	SNP: rs1556314, rs1785454, rs2010779, rs2096860, rs2238724, rs2238725, rs4818917, rs4818922, rs6518189, rs734336, rs8129542, rs933151, rs9974831, rs9984977 Haplotype: rs1556314 - rs9974831(), rs1785454 - rs933151(), rs2010779 - rs6518189(), rs2096860 - rs9984977(), rs2238724 - rs2238725(), rs2238725 - rs2010779(), rs4818917 - rs1556314(), rs6518189 - rs4818922(), rs734336 - rs2096860(), rs8129542 - rs2238724(), rs933151 - rs8129542(), rs9974831 - rs1785454(), rs9984977 - rs4818917()	A family-based association analysis of TRPM2 did not reveal any evidence for association of this gene with BPAD	Negative	Comment on Study
Xu, C., 2006	SNP: rs1612472, rs1618355, rs1785437, rs2838556, rs734336, rs749909, rs933151 Haplotype: rs734336 - rs2838556 - rs1785437 - rs1618355 - rs1612472 - rs933151 - rs749909 (T-T-T-C-T-T-A ), rs734336 - rs2838556 - rs1785437 - rs1618355 - rs1612472 - rs933151 - rs749909 (T-T-T-C-T-T-G ), rs734336 - rs2838556 - rs1785437 - rs1618355 - rs1612472 - rs933151 - rs749909 (C-C-C-G-C-C-A ), rs734336 - rs2838556 - rs1785437 - rs1618355 - rs1612472 - rs933151 - rs749909 (T-T-T-A-C-T-A ), rs734336 - rs2838556 - rs1785437 - rs1618355 - rs1612472 - rs933151 - rs749909 (T-T-C-C-C-C-A ), rs734336 - rs2838556 - rs1785437 - rs1618355 - rs1612472 - rs933151 - rs749909 (T-T-T-A-T-T-G ), rs734336 - rs2838556 - rs1785437 - rs1618355 - rs1612472 - rs933151 - rs749909 (T-T-C-C-C-C-G ), rs734336 - rs2838556 - rs1785437 - rs1618355 - rs1612472 - rs933151 - rs749909 (T-T-T-A-T-T-A )	These findings suggest genetic variants of the TRPM2 gene increase risk for BD and support the notion that TRPM2 may be involved in the pathophysiology of BD.	Positive	Comment on Study
Xu, C.,2012		A borderline interaction was found between rs749909 within TRPM2 and rs4375 within iPLA2beta (Puncorrected=0.009).A significant association of iPLA2beta variants with BD-I and a trend gene-gene interaction between iPLA2beta and TRPM2 provides additional support for the notion that genetic variation in these two functionally implicated candidates contributes toward the risk and pathophysiology of this illness.	Positive	Comment on Study
Xu, C.,2009	SNP: rs1556314, rs1618355, rs1785437, rs749909, rs933151	In conclusion, the evidence for association of TRPM2 variants with BD found in the current family-based and case-control designs adds further support to the two independent Caucasian casecontrol studies strengthening the notion that genetic variation of TRPM2 influences the susceptibility to BD.	Positive	Comment on Study

Region: chr21:44350163..44443081 View in gBrowse