Gene Report

Basic Info
Approved Symbol AKT1
Symbol Alias RAC, PKB, PRKBA, AKT
Approved Name v-akt murine thymoma viral oncogene homolog 1
Location 14q32.33
Position chr14:104769349-104795751, -1
External Links HGNC: 391
Entrez Gene: 207
Ensembl: ENSG00000142208
UCSC: uc001ypn.3
No. of Studies 3 (Positive: 3; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Karege, F.,2012 SNP: rs2494732, rs2498804, rs3803300 AKT1 gene variations appeared to impact the risk for a class of psychiatric symptoms, comprising SCZ and BPD. Our findings support the view that AKT1 genetic variants are shared by both BPD and SCZ. Positive Comment on Study
Toyota, T.,2003 Haplotype: (AKT1_1251C>T) - ( AKT1_IVS14+32G>A) - ( AKT1_IVS14+66C>G) - ( AKT1_IVS14+93C>T) - ( AKT1_IVS+95-98delCTCA)(C-G-C-C-del), (AKT1_1251C>T) - ( AKT1_IVS14+32G>A) - ( AKT1_IVS14+66C>G) - ( AKT1_IVS14+93C>T) - ( AKT1_IVS14+98A>G)(C-G-C-C-A), (AKT1_1251C>T) - ( AKT1_IVS14+32G>A) - ( AKT1_IVS14+66C>G) - ( AKT1_IVS14+93C>T) - ( AKT1_IVS14+98A>G)(C-G-G-C-A), (AKT1_1251C>T) - ( AKT1_IVS14+32G>A) - ( AKT1_IVS14+66C>G) - ( AKT1_IVS14+93C>T) - ( AKT1_IVS14+98A>G) - ( AKT1_IVS14+105_106ins_CTCAC or CTCAG)(C-G-C-C-G-insCTCAG) Transmission of haplotypes constructed from this cluster showed a weak evidence of association between the AKT1 and bipolar disorder. Positive Comment on Study
Karege, F.,2010 SNP: rs1130214, rs1130233, rs2494732, rs2498804, rs3730358, rs3803300
Haplotype: rs1130214 - rs3803300(), rs1130233 - rs3730358(), rs1130233 - rs3730358 - rs1130214(), rs1130233 - rs3730358 - rs1130214 - rs3803300(), rs2494732 - rs1130233(), rs2494732 - rs1130233 - rs3730358(), rs2494732 - rs1130233 - rs3730358 - rs1130214(), rs2494732 - rs1130233 - rs3730358 - rs1130214 - rs3803300(), rs2498804 - rs2494732(), rs2498804 - rs2494732 - rs1130233(), rs2498804 - rs2494732 - rs1130233 - rs3730358(), rs2498804 - rs2494732 - rs1130233 - rs3730358 - rs1130214(), rs2498804 - rs2494732 - rs1130233 - rs3730358 - rs1130214 - rs3803300(), rs3730358 - rs1130214(), rs3730358 - rs1130214 - rs3803300()
In conclusion, our findings, by showing the involvement of the AKT1 gene in both schizophrenia and bipolar disorder, support the role of AKT1 in the genetics of both disorders and add support to the view that there is some genetic overlap between them. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 132)

GO terms by PBA (count: 8)

GO terms by database search (count: 124)

Gene related KEGG pathways (count: 25)

Gene related BioCarta pathways (count: 30)

BioCarta pathways by PBA (count: 1)

BioCarta pathways by database search (count: 29)

Gene related interactors from protein-protein interactions data in HPRD (count: 103)

Related other genetic factors
Gene related SNPs (count: 12)

Literature-origin SNPs (count: 6)

LD-proxies (count: 6)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 2)

Overlap with SZ from candidate gene intersection analysis (count: 16)

Gene relationship with MDD

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Region: chr14:104769349..104795751 View in gBrowse
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