Gene Report

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Basic Info

Approved Symbol	HS3ST4
Symbol Alias	3OST4
Approved Name	heparan sulfate (glucosamine) 3-O-sulfotransferase 4
Location	16p11.2
Position	chr16:25692026-26137688, 1
External Links	HGNC: 5200 Entrez Gene: 9951 Ensembl: ENSG00000182601 UCSC: uc002dof.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0046. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030201	heparan sulfate proteoglycan metabolic process	biological process	NAS[9988767]	1
GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	molecular function	NAS[9988767]	1
GO:0000139	Golgi membrane	cellular component	IEA	36

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 16	chr16:0-90338345	5 (1/3/1)
16p12	chr16:16700000-28500000	2 (1/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr16:25692026..26137688 View in gBrowse