Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	MYT1L
Symbol Alias	KIAA1106, NZF1, ZC2HC4B
Approved Name	myelin transcription factor 1-like
Name Alias	neural zinc finger transcription factor 1
Location	2p25.3
Position	chr2:1789113-2331260, -1
External Links	HGNC: 7623 Entrez Gene: 23040 Ensembl: ENSG00000186487 UCSC: uc002qxd.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Hattori, E.,2009	SNP: rs10495483	After the two-stage analysis, markers in this gene remained nominally significant (allelic P<0.05) with the same allele being consistently over-represented in both the first and the follow-up stages.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 8)

GO terms by PBA (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030154	cell differentiation	biological process	IEA	31
GO:0005634	nucleus	cellular component	ISS	283
GO:0003677	DNA binding	molecular function	IEA	83
GO:0007399	nervous system development	biological process	IEA	40
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IEA	66

GO terms by database search (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0006355	regulation of transcription, DNA-templated	biological process	IEA	62
GO:0008270	zinc ion binding	molecular function	IEA	77

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 32)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs10495483	chr2:2194980 - 2194980(1)	intron_variant; non_coding_transcript_variant	1(1/0/0)

LD-proxies (count: 31)

rs_ID	Location	Functional Annotation
rs11675244	chr2:2177421 - 2177421(1)	intron_variant; non_coding_transcript_variant
rs17247345	chr2:2175408 - 2175408(1)	intron_variant; non_coding_transcript_variant
rs11674222	chr2:2174886 - 2174886(1)	intron_variant; non_coding_transcript_variant
rs11680102	chr2:2174155 - 2174155(1)	intron_variant; non_coding_transcript_variant
rs17247324	chr2:2191747 - 2191747(1)	intron_variant; non_coding_transcript_variant
rs6709211	chr2:2188978 - 2188978(1)	intron_variant; non_coding_transcript_variant
rs6705656	chr2:2187220 - 2187220(1)	intron_variant; non_coding_transcript_variant
rs964568	chr2:2179975 - 2179975(1)	intron_variant; non_coding_transcript_variant
rs17338519	chr2:2167333 - 2167333(1)	intron_variant; non_coding_transcript_variant
rs11127377	chr2:2165482 - 2165482(1)	intron_variant; non_coding_transcript_variant
rs17247359	chr2:2164892 - 2164892(1)	intron_variant; non_coding_transcript_variant
rs12474442	chr2:2163170 - 2163170(1)	intron_variant; non_coding_transcript_variant
rs11683072	chr2:2172405 - 2172405(1)	intron_variant; non_coding_transcript_variant
rs12467137	chr2:2171799 - 2171799(1)	intron_variant; non_coding_transcript_variant
rs17338505	chr2:2170137 - 2170137(1)	intron_variant; non_coding_transcript_variant
rs17338512	chr2:2169556 - 2169556(1)	intron_variant; non_coding_transcript_variant
rs11676685	chr2:2198331 - 2198331(1)	intron_variant; non_coding_transcript_variant
rs12467544	chr2:2199402 - 2199402(1)	intron_variant; non_coding_transcript_variant
rs11683093	chr2:2199453 - 2199453(1)	intron_variant; non_coding_transcript_variant
rs1990856	chr2:2200003 - 2200003(1)	intron_variant; non_coding_transcript_variant
rs6751879	chr2:2200593 - 2200593(1)	intron_variant; non_coding_transcript_variant
rs12471456	chr2:2201091 - 2201091(1)	intron_variant; non_coding_transcript_variant
rs12468168	chr2:2201123 - 2201123(1)	intron_variant; non_coding_transcript_variant
rs960813	chr2:2192223 - 2192223(1)	intron_variant; non_coding_transcript_variant
rs17039365	chr2:2193467 - 2193467(1)	intron_variant; non_coding_transcript_variant
rs12470060	chr2:2194535 - 2194535(1)	intron_variant; non_coding_transcript_variant
rs1862115	chr2:2194565 - 2194565(1)	intron_variant; non_coding_transcript_variant
rs12474706	chr2:2194737 - 2194737(1)	intron_variant; non_coding_transcript_variant
rs7596980	chr2:2195933 - 2195933(1)	intron_variant; non_coding_transcript_variant
rs7559324	chr2:2196231 - 2196231(1)	intron_variant; non_coding_transcript_variant
rs7607185	chr2:2196253 - 2196253(1)	intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2p25.3-p25.1	chr2:0-12000000	1 (1/0/0)
2p25.3-25.1	chr2:0-12000000	1 (0/1/0)
2p25	chr2:0-12000000	3 (0/1/2)
Chr 2	chr2:0-242193529	3 (0/3/0)
2q13-q14_126.907cM	chr2:0-4500000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

Reference	Description	Category in MDD	Link in MK4MDD
21048971	A haplotype of rs1617213 and rs6759709 G-C was significant (permutated p = 0.00007) different between cases and controls	Pos	MYT1L

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Region: chr2:1789113..2331260 View in gBrowse