BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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GO Report

Basic Info

ID	GO:0006811
Name	ion transport
Type	biological process
No. of Genes in BDgene	18
Source	Pathway by PBA

PBA Result

Pathway Name in Paper	Source	Reference	Data Set	Tool	Result Parameters	Result Link
ION TRANSPORT	i-GSEA analysis	Smith, E. N., Mol Psychiatry, 2009	dbGaP GAIN EA	i-GSEA by using i-GSEA4GWAS	P-value< 0.001, FDR=0.029923078	Link in i-GSEA4GWAS
GO: 0006811: ion transport	PBA paper	Askland, K.,2009	NIMH	Fisher's exact test	Results given for gene sets with P < 0.01 from the NIMH PBA-BP data

GO related genes in BDgene (count: 18)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)	Evidence[PMID]
SLC9A3	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3	5p15.3	1(1/0/0)	TAS
CHRNA2	cholinergic receptor, nicotinic, alpha 2 (neuronal)	8p21	3(0/3/0)	NAS[8906617]
SLC1A4	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4	2p15-p13	1(0/1/0)	TAS
SLC12A6	solute carrier family 12 (potassium/chloride transporter), member 6	15q13	1(1/0/0)	IDA[10187864]; TAS
SLC20A1	solute carrier family 20 (phosphate transporter), member 1	2q13	1(0/1/0)	TAS
SLC22A23	solute carrier family 22, member 23	6p25.2	1(1/0/0)	IEA
GLRA1	glycine receptor, alpha 1	5q33.1	1(1/0/0)	IDA[2155780]
SLC15A1	solute carrier family 15 (oligopeptide transporter), member 1	13q32.3	1(0/1/0)	TAS
CHRNA4	cholinergic receptor, nicotinic, alpha 4 (neuronal)	20q13.33	1(1/0/0)	NAS[8906617]
MLC1	megalencephalic leukoencephalopathy with subcortical cysts 1	22q13.33	5(1/4/0)	IEA
CHRNA3	cholinergic receptor, nicotinic, alpha 3 (neuronal)	15q24	3(1/2/0)	NAS[8906617]
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	11p13-p12	1(1/0/0)	TAS
CNNM4	cyclin and CBS domain divalent metal cation transport mediator 4	2q11.2	1(1/0/0)	IEA
CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)	1q21.3	1(1/0/0)	NAS[8906617]
CHRNA7	cholinergic receptor, nicotinic, alpha 7 (neuronal)	15q13.3	4(2/2/0)	NAS[8906617]
SLC1A1	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	9p24	1(1/0/0)	TAS
GABRB1	gamma-aminobutyric acid (GABA) A receptor, beta 1	4p12	3(2/0/1)	ISS
CHRNB4	cholinergic receptor, nicotinic, beta 4 (neuronal)	15q24	2(1/1/0)	TAS[8906617]