Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	CD276
Symbol Alias	B7-H3, B7H3, B7RP-2
Approved Name	CD276 molecule
Previous Name	CD276 antigen
Location	15q23-q24
Position	chr15:73683966-73714518, 1
External Links	HGNC: 19137 Entrez Gene: 80381 Ensembl: ENSG00000103855 UCSC: uc002avv.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Smith, E. N.,2011	SNP: rs1038094	No significant association of this gene was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005102	receptor binding	molecular function	NAS[11224528]	37
GO:0016021	integral component of membrane	cellular component	NAS[15188059]	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0050728	negative regulation of inflammatory response	biological process	IEA	6
GO:0042110	T cell activation	biological process	IDA[18650384]	9
GO:0042102	positive regulation of T cell proliferation	biological process	IDA[11224528]	6
GO:1900042	positive regulation of interleukin-2 secretion	biological process	IEA	1
GO:0045078	positive regulation of interferon-gamma biosynthetic process	biological process	IDA[11224528]	1
GO:0045077	negative regulation of interferon-gamma biosynthetic process	biological process	IEA	1
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0005515	protein binding	molecular function	IPI[18650384]	563
GO:0008283	cell proliferation	biological process	NAS[11224528]	37
GO:0045085	negative regulation of interleukin-2 biosynthetic process	biological process	IEA	1
GO:0006955	immune response	biological process	NAS[11224528]	19
GO:0030501	positive regulation of bone mineralization	biological process	IEA	4
GO:0009897	external side of plasma membrane	cellular component	NAS[15188059]	21
GO:0045669	positive regulation of osteoblast differentiation	biological process	IEA	7
GO:0042130	negative regulation of T cell proliferation	biological process	IEA	6
GO:0050776	regulation of immune response	biological process	NAS[11224528]	4

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04514	Cell adhesion molecules (CAMs)	14

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1038094	chr15:73720096 - 73720096(1)		1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
15q24.1-25.2	chr15:72400000-84700000	1 (0/1/0)
Chr 15	chr15:0-101991189	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr15:73683966..73714518 View in gBrowse