Gene Report

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Basic Info

Approved Symbol	ADSSL1
Symbol Alias	FLJ38602
Approved Name	adenylosuccinate synthase like 1
Location	14q32.33
Position	chr14:104724186-104747325, 1
External Links	HGNC: 20093 Entrez Gene: 122622 Ensembl: ENSG00000185100 UCSC: uc001ype.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gonzalez, S., 2014	SNP: rs6644	The associated SNP in this gene showed no significant association with BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0051015	actin filament binding	molecular function	IEA	9
GO:0042301	phosphate ion binding	molecular function	NAS[15786719]	1

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005737	cytoplasm	cellular component	IDA[15786719]	322
GO:0003924	GTPase activity	molecular function	IEA	14
GO:0035690	cellular response to drug	biological process	IEA	13
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0044208	'de novo' AMP biosynthetic process	biological process	IBA; IEA	2
GO:0002376	immune system process	biological process	NAS[15786719]	3
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	biological process	TAS	2
GO:0046040	IMP metabolic process	biological process	IBA	2
GO:0071257	cellular response to electrical stimulus	biological process	IEA	1
GO:0006167	AMP biosynthetic process	biological process	IDA[15786719]	2
GO:0006144	purine nucleobase metabolic process	biological process	TAS	3
GO:0005829	cytosol	cellular component	TAS	223
GO:0055086	nucleobase-containing small molecule metabolic process	biological process	TAS	4
GO:0042594	response to starvation	biological process	IEA	8
GO:0000287	magnesium ion binding	molecular function	IEA	11
GO:0004019	adenylosuccinate synthase activity	molecular function	IDA[15786719]	1
GO:0042803	protein homodimerization activity	molecular function	IEA	71
GO:0014850	response to muscle activity	biological process	IEA	2
GO:0006531	aspartate metabolic process	biological process	IEA	2
GO:0005525	GTP binding	molecular function	NAS[15786719]	20
GO:0006541	glutamine metabolic process	biological process	IEA	1

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00230	Purine metabolism	12

ID	Name	No. of Genes in BDgene	Brief Description
hsa00252	Alanine and aspartate metabolism	5

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6644	chr14:104747006 - 104747006(1)	3_prime_UTR_variant; downstream_gene_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1(0/1/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs7160733		chr14:104737341 - 104737341(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant
rs4983384		chr14:104741720 - 104741720(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q32	chr14:89300000-107043718	1 (0/1/0)
Chr 14	chr14:0-107043718	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr14:104724186..104747325 View in gBrowse