Gene Report

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Basic Info

Approved Symbol	ADAM18
Symbol Alias	tMDCIII, ADAM27
Approved Name	ADAM metallopeptidase domain 18
Previous Name	a disintegrin and metalloproteinase domain 18
Location	8p11.22
Position	chr8:39584489-39730064, 1
External Links	HGNC: 196 Entrez Gene: 8749 Ensembl: ENSG00000168619 UCSC: uc003xni.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Georgi, B., 2014	SNP: rs147445686	Amish-specific putative damaging exonic missense variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0004222	metalloendopeptidase activity	molecular function	IEA	8
GO:0030154	cell differentiation	biological process	IEA	31
GO:0008237	metallopeptidase activity	molecular function	TAS[10395895]	8
GO:0016020	membrane	cellular component	TAS[10395895]	137
GO:0007275	multicellular organismal development	biological process	IEA	24

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007283	spermatogenesis	biological process	IEA	29
GO:0008270	zinc ion binding	molecular function	IEA	77
GO:0006508	proteolysis	biological process	IEA	34

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs147445686	chrCHR_HSCHR8_9_CTG1:39508806 - 39508806(1)	3_prime_UTR_variant; missense_variant; NMD_transcript_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 8	chr8:0-145138636	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr8:39584489..39730064 View in gBrowse