Gene Report

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Basic Info

Approved Symbol	NXN
Symbol Alias	FLJ12614, NRX
Approved Name	nucleoredoxin
Location	17p13
Position	chr17:799313-979770, -1
External Links	HGNC: 18008 Entrez Gene: 64359 Ensembl: ENSG00000167693 UCSC: uc002fsa.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Ollila, H. M.,2009	SNP: rs2360111	It showed no evidence for association with BPI in our study.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030154	cell differentiation	biological process	IEA	31
GO:0005634	nucleus	cellular component	IEA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0055114	oxidation-reduction process	biological process	IEA	43
GO:0047134	protein-disulfide reductase activity	molecular function	IEA	1
GO:0072358	cardiovascular system development	biological process	ISS	1
GO:0005829	cytosol	cellular component	IEA	223
GO:0031397	negative regulation of protein ubiquitination	biological process	ISS	6
GO:0016055	Wnt signaling pathway	biological process	IEA	12
GO:0004791	thioredoxin-disulfide reductase activity	molecular function	IEA	1
GO:0030178	negative regulation of Wnt signaling pathway	biological process	ISS	5

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NXN	PPP2CA	NO	in vitro;in vivo	16764867

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2360111	chr17:928427 - 928427(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant	2(0/2/0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Kember[2015]_32	chr17:811982-1183612 (UCSC build 37, hg19)	456481		duplication

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
17p13	chr17:0-10800000	3 (0/3/0)
Chr 17	chr17:0-83257441	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr17:799313..979770 View in gBrowse